LaboratoryofPublic Health, Graduate School of Veterinary Medicine, Hokkaido University, Japan; Clinical Studies Department, School of Veterinary Medicine, University of Zambia, Zambia.
Microbiol Immunol. 2014 Feb;58(2):112-8. doi: 10.1111/1348-0421.12122.
This study focused on the antigenic cross-reactivity between tick-borne encephalitis virus (TBEV) and Omsk hemorrhagic fever virus (OHFV) to assess the efficacy of the commercial TBE vaccine against OHFV infection. Neutralization tests performed on sera from OHFV- and TBEV-infected mice showed that neutralizing antibodies are cross-protective. The geometric mean titers of antibodies against TBEV and OHFV from TBEV-infected mice were similar. However, the titers of anti-TBEV antibodies in OHFV-infected mice were significantly lower than those of anti-OHFV antibodies in the same animals. In mouse vaccination and challenge tests, the TBE vaccine provided 100% protection against OHFV infection. Eighty-six percent of vaccinees seroconverted against OHFV following complete vaccination, and the geometric mean titers of neutralizing antibodies against OHFV were comparable to those against TBEV. These data suggest that the TBE vaccine can prevent OHFV infection.
本研究关注蜱传脑炎病毒（TBEV）和鄂木斯克出血热病毒（OHFV）之间的抗原交叉反应，以评估商业 TBE 疫苗对 OHFV 感染的效果。对感染 OHFV 和 TBEV 的小鼠血清进行的中和试验表明，中和抗体具有交叉保护作用。TBEV 感染小鼠的 TBEV 和 OHFV 抗体的几何平均滴度相似。然而，在 OHFV 感染的小鼠中，抗 TBEV 抗体的滴度明显低于同一动物中抗 OHFV 抗体的滴度。在小鼠接种和挑战试验中，TBE 疫苗对 OHFV 感染提供了 100%的保护。完全接种疫苗后，86%的疫苗接种者针对 OHFV 发生血清转化，针对 OHFV 的中和抗体的几何平均滴度与针对 TBEV 的滴度相当。这些数据表明，TBE 疫苗可以预防 OHFV 感染。
