Institution of Medicine, Unit for Infectious Diseases, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden.
Vaccine. 2010 Apr 1;28(16):2827-31. doi: 10.1016/j.vaccine.2010.02.001. Epub 2010 Feb 16.
Tick-borne encephalitis (TBE) is a major disease of the central nervous system in Europe and is endemic in Sweden with about 200 notified cases annually. The far most effective protective measure against TBE is active immunisation. The vaccines available today induce a high degree of protection in field studies. However, vaccine failures have occasionally been reported and may be overlooked due to different, and sometimes confusing, antibody kinetics in vaccinees with TBEV infection. In this study, 27 patients with clinical and serological evidences of TBE despite adequate immunisation are presented. Vaccination failure is characterized by a slow, and initially non-detectable, development of the specific TBEV-IgM response, seen together with a rapid rise of IgG and neutralising antibodies in serum. The majority (70%) of the patients were more than 50 years of age, which may implicate a need for a modified immunisation strategy in the elderly.
蜱传脑炎（TBE）是欧洲一种主要的中枢神经系统疾病，在瑞典流行，每年有大约 200 例报告病例。预防 TBE 最有效的方法是主动免疫。目前可用的疫苗在现场研究中诱导出高度的保护。然而，疫苗接种失败的情况时有发生，由于 TBEV 感染的疫苗接种者的抗体动力学不同，有时甚至令人困惑，因此可能会被忽视。在这项研究中，报告了 27 例有临床和血清学证据的 TBE 患者，尽管进行了充分的免疫接种。疫苗接种失败的特点是特异性 TBEV-IgM 反应的发展缓慢，最初无法检测到，同时血清中 IgG 和中和抗体迅速上升。大多数（70%）患者年龄超过 50 岁，这可能意味着老年人需要修改免疫策略。
