Pettingale K W, Burgess C, Greer S
Faith Courtauld Unit for Human Studies in Cancer, King's College School of Medicine and Dentistry, London, U.K.
J Psychosom Res. 1988;32(3):255-61. doi: 10.1016/0022-3999(88)90066-9.
A prospective, multidisciplinary study of 168 newly diagnosed patients with early breast cancer and Hodgkin's or non-Hodgkin's lymphoma was conducted. Psychological assessments were conducted at 3 and 12 months following diagnosis and correlated with clinical and pathological variables. There was no statistical association between psychological response to breast cancer and any other prognostic variable measured. In lymphoma patients of both groups there was evidence of greater psychiatric morbidity in those with more advanced disease and those who failed to respond to treatment. However there was also no statistical association between any cognitive response category and known prognostic variables. There was no evidence that the patient's gender or type of tumour affected their overall mental adjustment to cancer and the effect described in breast cancer may apply to all types of malignant disease.
对168例新诊断的早期乳腺癌及霍奇金淋巴瘤或非霍奇金淋巴瘤患者进行了一项前瞻性多学科研究。在诊断后的3个月和12个月进行了心理评估,并将其与临床和病理变量相关联。乳腺癌患者的心理反应与所测量的任何其他预后变量之间无统计学关联。在两组淋巴瘤患者中,有证据表明疾病进展程度较高及对治疗无反应者的精神疾病发病率更高。然而,任何认知反应类别与已知预后变量之间也无统计学关联。没有证据表明患者的性别或肿瘤类型会影响其对癌症的整体心理调适,乳腺癌中所描述的影响可能适用于所有类型的恶性疾病。