J Breath Res. 2020 May 13;14(3):034002. doi: 10.1088/1752-7163/ab6229.
Legalization of cannabis for recreational use has compelled governments to seek new tools to accurately monitor Δ9-tetrahydrocannabinol (Δ9-THC) and understand its effect on impairment. Various methods have been employed to measure Δ9-THC, and its respective metabolites, in different biological matrices. Recently, breath analysis has gained interest as a non-invasive method for the detection of chemicals that are either produced as part of biological processes or are absorbed from the environment. Existing breath analyzers function by analyzing previously collected samples or by direct real-time analysis. Portable hand-held devices are of particular interest for law enforcement and personal use. This paper reviews and compares both commercially available and prototype devices that proclaim Δ9-THC detection in exhaled breath using methods such as Field Asymmetric Ion Mobility Spectrometry, Semiconductor-Enriched Single-Walled Carbon Nanotube chemiresistors, Liquid Chromatography Tandem-mass Spectrometry, microfluidic-based artificial olfaction, and optical-based gas sensing.
大麻娱乐用途合法化促使各国政府寻求新工具，以准确监测 Δ9-四氢大麻酚 (Δ9-THC) 并了解其对损伤的影响。已经采用了各种方法来测量不同生物基质中的 Δ9-THC 及其各自的代谢物。最近，呼吸分析作为一种非侵入性方法，用于检测生物过程中产生的或从环境中吸收的化学物质，引起了人们的兴趣。现有的呼吸分析仪通过分析先前收集的样本或直接实时分析来工作。便携式手持设备特别受执法部门和个人使用的关注。本文综述并比较了商用和原型设备，这些设备使用现场不对称离子迁移谱、半导体富集单壁碳纳米管化学电阻器、液相色谱串联质谱、基于微流控的人工嗅觉和基于光学的气体传感等方法来宣称检测呼气中的 Δ9-THC。
