Ramzy Veronika, Priefer Ronny
Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, 02115, USA.
Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, 02115, USA.
Talanta. 2021 Jan 15;222:121528. doi: 10.1016/j.talanta.2020.121528. Epub 2020 Aug 11.
Cannabis legalization and common use has further driven the need for accurate THC detection and analysis for roadside testing. While reliable and accurate techniques, such as mass spectrometry (MS) exist for the analysis of THC, the market lacks technologies that are portable and can be utilized outside of a laboratory setting. Innovations utilizing unique technologies have steadily been increasing. These include carbon nanotubes, specifically semiconductor-enriched single-walled carbon nanotube (s-SWCNT) chemiresistors and carbon nanotubes with integrated molecularly imprinted polymers (MIPs), giant magnetoresistive (GMR) biosensors, capillary electrophoresis (CE) with ultraviolet light-emitting diode-induced native fluorescence (UV-LEDIF), and electrochemical detection with the use of screen printed carbon electrodes and N-(4-amino-3-methoxyphenyl)-methanesulfonamide. Finally, a novel device has been recently launched to detect THC in the breath with the use of TLC and fluorescent probes. This review highlights the technologies that have been, and are being, explored to ultimately lead to a portable road-side test for THC once further testing in practice has been completed.
大麻合法化及广泛使用进一步推动了对路边检测中准确检测和分析四氢大麻酚（THC）的需求。虽然存在可靠且准确的技术，如质谱分析法（MS）用于分析THC，但市场上缺乏便携式且可在实验室环境之外使用的技术。利用独特技术的创新一直在稳步增加。这些技术包括碳纳米管，特别是富含半导体的单壁碳纳米管（s-SWCNT）化学电阻器和集成分子印迹聚合物（MIP）的碳纳米管、巨磁阻（GMR）生物传感器、采用紫外发光二极管诱导天然荧光（UV-LEDIF）的毛细管电泳（CE），以及使用丝网印刷碳电极和N-(4-氨基-3-甲氧基苯基)-甲磺酰胺的电化学检测。最后，最近推出了一种新颖的设备，利用薄层色谱法（TLC）和荧光探针检测呼出气体中的THC。这篇综述重点介绍了那些已经和正在探索的技术，以便一旦在实际中完成进一步测试，最终能实现对THC的便携式路边检测。
