用于同时进行生物成像和增强协同治疗的小型上转换纳米晶体的优越温度感应。
Superior temperature sensing of small-sized upconversion nanocrystals for simultaneous bioimaging and enhanced synergetic therapy.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China; Coherent Light and Atomic and Molecular Spectroscopy Laboratory, Key Laboratory of Physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun, China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
出版信息
Nanomedicine. 2020 Feb;24:102135. doi: 10.1016/j.nano.2019.102135. Epub 2019 Dec 14.
The upconversion nanoparticles (UCNPs) exhibit versatility applications aiming at biological domains for decades on account of superior optical characteristics. Nevertheless, the UCNPs are confronted with tremendous difficulties in biological field owing to large grain size, low fluorescence efficiency, and single function. Herein, the small-sized CaF: Yb/Er UCNPs coated with NaGdF shells (activator and inert, UCNPs-RBHA-Pt-PEG) not only burst out strong fluorescence, but also provide prominent diagnosability by taking advantage of magnetic resonance (MR) imaging as well as temperature sensing and inhibiting capability for CT26 tumor tissues based on synergetic therapy modality of photodynamic therapy (PDT) and chemotherapy. Ultimately, the tumor sizes decrease visibly after injected with UCNPs-RBHA-Pt-PEG and simultaneously irradiated with near infrared (NIR) light at low power density (0.35 W/cm, 6 min). In summary, the small-sized and strong-fluorescent single nanoparticles with multi-functions may provide a valuable enlightenment for diagnosis and treatment of cancer in the future.
上转换纳米粒子（UCNPs）因其优异的光学特性，几十年来在生物领域表现出多种应用潜力。然而，由于粒径大、荧光效率低和功能单一，UCNPs 在生物领域面临着巨大的困难。在此，我们制备了具有小尺寸、强荧光的 NaGdF 壳包覆的 CaF: Yb/Er UCNPs（激活剂和惰性，UCNPs-RBHA-Pt-PEG），不仅能发出强荧光，还能利用磁共振成像（MRI）以及温度感应，并基于光动力治疗（PDT）和化学疗法的协同治疗模式，对 CT26 肿瘤组织表现出明显的诊断能力和抑制能力。最后，在低功率密度（0.35 W/cm，6 分钟）的近红外（NIR）光照射下，注射 UCNPs-RBHA-Pt-PEG 后，肿瘤大小明显减小。总之，具有多功能的小尺寸、强荧光的单纳米粒子可能为癌症的诊断和治疗提供有价值的启示。
Zotero 插件