Laboratory of Functionalized Molecular Solids, Ministry of Education Anhui Key Laboratory of Chemo/Biosensing Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB) College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, P.R. China.
Department of Chemistry and Chemical Engineering, Hefei Normal University, Hefei, 230061, P.R. China).
Chem Asian J. 2022 Jul 15;17(14):e202200161. doi: 10.1002/asia.202200161. Epub 2022 May 18.
Here, NaGdF ,Yb,Er@NaGdF ,Yb,Tm@NaYF core@shell@shell three-layer structure of upconversion nanoparticles (UCNPs) coated with Fe-Tetrakis (4-carboxyphenyl) porphine (TCPP) metal-organic frameworks (Fe-MOFs) nanocomposite (UCNPs@MOFs) was designed and constructed for multimodal imaging and synergetic chemodynamic therapy (CDT)/photodynamic therapy (PDT) of tumors. The UCNPs@MOFs were successfully applied for tumor cells imaging in vitro and in vivo in near-infrared (NIR) region. The doped Gd was used as contrast agent for the magnetic resonance imaging (MRI) of mouse tumors. The luminescence in the UV-vis region was absorbed by the Fe-MOFs to produce singlet oxygen ( O ) for PDT. The Fe doped in the MOFs can catalyze H O to produce oxygen and hydroxyl radical (⋅OH). Hydroxyl radical is used in CDT and cooperates with the O of PDT. Based on the CDT/PDT synergistic effects, the UCNPs@MOFs nanocomposite had obviously enhanced tumor inhibitory efficiency in vivo. These results described that the asprared UCNPs@MOFs nanocomposite have great potential in the effective multimodal imaging and treatment of tumors.
这里，NaGdF,Yb,Er@NaGdF,Yb,Tm@NaYF 核壳壳三层结构的上转换纳米粒子（UCNPs）涂有 Fe-四（4-羧基苯基）卟啉（TCPP）金属有机骨架（Fe-MOFs）纳米复合材料（UCNPs@MOFs）被设计和构建用于肿瘤的多模态成像和协同化学动力学治疗（CDT）/光动力治疗（PDT）。UCNPs@MOFs 成功地应用于近红外（NIR）区域的肿瘤细胞体外和体内成像。掺杂的 Gd 被用作小鼠肿瘤磁共振成像（MRI）的造影剂。UV-vis 区域的发光被 Fe-MOFs 吸收，产生用于 PDT 的单线态氧（ O ）。Fe 掺杂在 MOFs 中可以催化 H O 产生氧气和羟基自由基（⋅OH）。羟基自由基用于 CDT，并与 PDT 的 O 协同作用。基于 CDT/PDT 的协同效应，UCNPs@MOFs 纳米复合材料在体内明显增强了肿瘤抑制效率。这些结果表明，所提出的 UCNPs@MOFs 纳米复合材料在肿瘤的有效多模态成像和治疗方面具有巨大的潜力。
