Sautreuil Camille, Laquerrière Annie, Lecuyer Matthieu, Brasse-Lagnel Carole, Jégou Sylvie, Bekri Soumeya, Marcorelles Pascale, Gil Sophie, Marret Stéphane, Gonzalez Bruno J
Inserm U1245, Équipe 4, Rouen Université, Normandie Université, Rouen, France.
Inserm U1245, Équipe 4, Rouen Université, Normandie Université, Rouen, France - Service de Pathologie, Hôpital Charles-Nicolle, CHU de Rouen, France.
Med Sci (Paris). 2019 Nov;35(11):859-865. doi: 10.1051/medsci/2019167. Epub 2019 Dec 17.
Alcohol consumption during pregnancy constitutes a major cause of neurodevelopmental and behavioral disabilities. Whereas it is possible for clinicians to establish a perinatal diagnosis of fetal alcohol syndrome, the more severe expression of fetal alcohol spectrum disorder (FASD), most FASD children are late or mis-diagnosed due to a lack of clear morphological and neurodevelopmental abnormalities. Several precious years of care are consequently lost. Recent data revealed a functional placenta-brain axis involved in the control of the fetal brain angiogenesis which is impaired by in utero alcohol exposure. Because in the developing fetal brain a correct angiogenesis is required for a correct neurodevelopment, these preclinical and clinical advances pave the way for a new generation of placental biomarkers for early diagnosis of FASD.
孕期饮酒是导致神经发育和行为障碍的主要原因。虽然临床医生有可能对胎儿酒精综合征进行围产期诊断，但胎儿酒精谱系障碍（FASD）的表现更为严重，由于缺乏明显的形态学和神经发育异常，大多数FASD儿童诊断较晚或被误诊。因此失去了宝贵的数年治疗时间。最近的数据显示，存在一条功能性胎盘-脑轴，参与胎儿脑血管生成的控制，而宫内酒精暴露会损害这一过程。由于在发育中的胎儿大脑中，正确的血管生成是正常神经发育所必需的，这些临床前和临床研究进展为新一代用于FASD早期诊断的胎盘生物标志物铺平了道路。
