Liu K, Zhang F, Xiao C L, Xia H Z, Hao Y C, Bi H, Zhao L, Liu Y Q, Lu J, Ma L L
Department of Urology, Peking University Third Hospital, Beijing 100191, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2019 Dec 18;51(6):1159-1164. doi: 10.19723/j.issn.1671-167X.2019.06.032.
To evaluate the safety and efficacy of the seven-step two-lobe holmium laser enucleation of the prostate (HoLEP) technique with low power laser device, and to introduce the detailed operating procedures, key points, short-term outcomes of this modified HoLEP technique.
From March 2016 to November 2017, 90 patients underwent HoLEP in Peking University Third Hospital. The patients were divided into two groups: high-power group (32 patients) were performed with traditional Gilling's three-lobe enucleation using high power (90 W) laser; Low-power group (58 patients) were performed with seven-step two-lobe enucleation using low power (40 W) laser. The main steps of the low power seven-step two-lobe HoLEP phase included: (1) The identification of the correct plane between adenoma and capsule at 5 and 7 o'clock laterally to the veru montanum; (2) The connection of the bilateral plane by making a adenoma incision at the proximal point of veru montanum; (3) The extension of the dorsal plane under the whole three lobes between adenoma and capsule towards the bladder neck; (4) The separation of the middle lobe from two lateral lobes by making two retrograde incisions separately from apex 5 and 7 o'clock towards the bladder neck; (5) The enucleation of the middle lobe adenoma by extending the dorsal plane through into the bladder; (6) The prevention of the apex mucosa by making a circle incision at the apex of the prostate; (7) The en-bloc enucleation of the two lateral lobe adenomas by extending the lateral and ventral plane between adenoma and capsule from 5 and 7 o'clock to 12 o'clock conjunction and through into the bladder.
The mean patient age was (66.25±5.37) years vs. (68.00±5.18) years; The mean body mass indexes were (24.13±4.06) kg/m vs. (24.57±3.50) kg/m; The mean prostate specific antigen values were (3.23±2.47) μg/L vs. (6.00±6.09) μg/L; The average prostatic volumes evaluated by ultrasound was (49.03±20.63) mL vs. (67.55±36.97) mL. There was no significant difference between the two groups. Furthermore, there were no significant differences in terms of perioperative and follow up data, including operative time; enucleation efficiencies; hemoglobin decrease; blood sodium and potassiumthe change postoperatively; catheterization duration and hospital stay; the international prostate symptom scores and quality of life scores pre- and post-operatively. There was 1 transurethral resection of the prostate (TURP) conversion in high-power group and 1 transfusion in low-power group during the operations. The follow-up one month after operation showed no severe stress incontinence in both the groups, whereas 3 cases ejaculatory dysfunctions in high-power group versus 1 case in low-power group were observed; Other surgeryrelated complications included: 2 cases postoperative hemorrhage (Clavien II and Clavien IIIb) in high-power group, 2 cases postoperative temperature more than 38 °C (Clavien I) and 1 case dysuria following catheter removal (Clavien I) in low-power group.
Low power laser device can be applied safe and effectively for HoLEP procedure using the seven-step two-lobe HoLEP technique. The outcomes comparable with high power laser HoLEP can be achieved.
评估使用低功率激光设备的七步法两叶钬激光前列腺剜除术(HoLEP)技术的安全性和有效性,并介绍这种改良HoLEP技术的详细操作步骤、要点及短期结果。
2016年3月至2017年11月,90例患者在北京大学第三医院接受HoLEP手术。患者分为两组:高功率组(32例)采用传统的Gilling三步法三叶剜除术,使用高功率(90W)激光;低功率组(58例)采用七步法两叶剜除术,使用低功率(40W)激光。低功率七步法两叶HoLEP阶段的主要步骤包括:(1)在前列腺小囊外侧5点和7点处识别腺瘤与包膜之间的正确平面;(2)在前列腺小囊近端做腺瘤切口连接双侧平面;(3)在腺瘤与包膜之间的整个三叶下方将背侧平面延伸至膀胱颈;(4)分别从5点和7点尖部向膀胱颈做两条逆行切口,将中叶与两侧叶分离;(5)通过将背侧平面延伸至膀胱,剜除中叶腺瘤;(6)在前列腺尖部做环形切口,保护尖部黏膜;(7)将腺瘤与包膜之间的外侧和腹侧平面从5点和7点延伸至12点连接并延伸至膀胱,将两侧叶腺瘤整块剜除。
两组患者的平均年龄分别为(66.25±5.37)岁和(68.00±5.18)岁;平均体重指数分别为(24.13±4.06)kg/m和(24.57±3.50)kg/m;平均前列腺特异性抗原值分别为(3.23±2.47)μg/L和(6.00±6.09)μg/L;超声评估的平均前列腺体积分别为(49.03±20.63)mL和(67.55±36.97)mL。两组之间无显著差异。此外,围手术期和随访数据,包括手术时间、剜除效率、血红蛋白下降、术后血钠和血钾变化、导尿持续时间和住院时间、术前和术后国际前列腺症状评分及生活质量评分,均无显著差异。高功率组手术中有1例转为经尿道前列腺切除术(TURP),低功率组有1例输血。术后1个月随访显示,两组均无严重压力性尿失禁,高功率组观察到3例射精功能障碍,低功率组观察到1例;其他手术相关并发症包括:高功率组2例术后出血(Clavien II和Clavien IIIb),低功率组2例术后体温超过38℃(Clavien I)和1例拔管后排尿困难(Clavien I)。
低功率激光设备可安全有效地应用于七步法两叶HoLEP技术的HoLEP手术。可获得与高功率激光HoLEP相当的结果。