Wollina Uwe, Bitel Alena, Vojvodic Aleksandra, Lotti Torello
Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.
Military Medical Academy of Belgrade, Belgrade, Serbia.
Open Access Maced J Med Sci. 2019 Aug 20;7(18):2998-3001. doi: 10.3889/oamjms.2019.536. eCollection 2019 Sep 30.
Actinic keratoses (AKs) are precancerous epidermal lesions induced by chronic exposure to ultraviolet light. Several topical and surgical treatments are available. For field cancerization, photodynamic therapy (PDT) is a very effective noninvasive treatment with excellent outcome and cosmesis. The management of treatment-associated adverse events, however, is crucial to achieve the treatment aims and to ensure patients adherence to PDT.
We report on adverse events and their management related to PDT. We conducted literature research on PUBMED (R). Also, we present a case of an uncommon adverse event-PDT-induced rosacea flare-up on scalp and eyes. The patient was treated successfully by submicrobial slow-release doxycycline orally.
PDT is an excellent treatment option for multiple AKs such as in bald scalp field cancerization. The management of adverse events during and after PDT is an essential part of a successful treatment plan.
光化性角化病（AKs）是长期暴露于紫外线引起的癌前表皮病变。有多种局部和手术治疗方法。对于场癌化，光动力疗法（PDT）是一种非常有效的非侵入性治疗方法，效果良好且美容效果佳。然而，处理与治疗相关的不良事件对于实现治疗目标和确保患者坚持 PDT 治疗至关重要。
我们报告了与 PDT 相关的不良事件及其处理方法。我们在 PUBMED（R）上进行了文献研究。此外，我们还展示了一例罕见的不良事件——PDT 诱发头皮和眼部酒渣鼻样皮疹。该患者通过口服亚微生物缓释强力霉素成功治愈。
PDT 是治疗如秃头皮场癌化等多发性 AKs 的极佳治疗选择。PDT 治疗期间及之后对不良事件的处理是成功治疗计划的重要组成部分。
