Wu Xuelin, Hu Yongxuan
Department of Dermatology and Venereology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, People's Republic of China.
Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, People's Republic of China.
Infect Drug Resist. 2022 Jun 21;15:3251-3266. doi: 10.2147/IDR.S369605. eCollection 2022.
Cutaneous fungal infections are common in humans and are associated with significant physical and psychological distress to patients. Although conventional topical and/or oral anti-fungal medications are commonly recommended treatments, drug resistance has emerged as a significant concern in this patient population, and safer, more efficacious, and cost-effective alternatives are warranted. Recent studies have reported effectiveness of photodynamic therapy (PDT) against fungal infections without severe adverse effects. In this review, we briefly discuss the mechanisms underlying PDT, current progress, adverse effects, and limitations of this treatment in the management of superficial and deep fungal infections.
皮肤真菌感染在人类中很常见，会给患者带来极大的身心痛苦。尽管传统的局部和/或口服抗真菌药物是常用的推荐治疗方法，但耐药性已成为这一患者群体的一个重大问题，因此需要更安全、更有效且更具成本效益的替代方案。最近的研究报告了光动力疗法（PDT）治疗真菌感染的有效性，且无严重不良反应。在这篇综述中，我们简要讨论了光动力疗法的潜在机制、当前进展、不良反应以及该疗法在治疗浅表和深部真菌感染方面的局限性。
