甜蜜的诱惑：从糖代谢到基因调控。
Sweet Temptation: From Sugar Metabolism to Gene Regulation.
机构信息
Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Immunity. 2019 Dec 17;51(6):980-981. doi: 10.1016/j.immuni.2019.11.008.
PMID:31851904
Abstract
In a recent issue of Nature, Zhang et al. (2019) describe an additional histone post-translational modification, named histone lactylation. Following increased lactate production as a consequence of M1 polarization, histone lactylation regulates the induction of an M2-like phenotype in late stages of M1 macrophage activation to promote wound healing.
摘要
在最近一期的《自然》杂志上，Zhang 等人（2019 年）描述了一种额外的组蛋白翻译后修饰，命名为组蛋白乳酰化。在 M1 极化导致乳酸生成增加后，组蛋白乳酰化调节 M1 巨噬细胞活化晚期向 M2 样表型的诱导，以促进伤口愈合。
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