Gerhart E H, Carlson R M
Department of Chemistry, University of Minnesota, Duluth 55812.
Environ Res. 1978 Oct;17(2):284-95. doi: 10.1016/0013-9351(78)90031-2.
The effects of polycyclic aromatic hydrocarbons (PAHs) on microsomal liver enzymes were examined in rainbow trout. Various PAHs (naphthalene through benzo(a)pyrene [B(a)P]) were injected ip to screen for mixed-function oxidase (MFO) activity. Chrysene, B(a)P, and Aroclor 1254 caused MFO induction. When fish were also exposed to solubilized pyrene, fluoranthene, and B(a)P in water, bioaccumulation of B(a)P resulted in MFO induction, whereas bioaccumulation of pyrene and fluoranthene did not. Based on water and injection exposure to B(a)P, it was predicted that tissue concentrations in excess of 300 micrograms/kg B(a)P would be accompanied by MFO induction in rainbow trout.
在虹鳟鱼中研究了多环芳烃（PAHs）对微粒体肝酶的影响。通过腹腔注射各种PAHs（从萘到苯并(a)芘[B(a)P]）来筛选混合功能氧化酶（MFO）活性。屈、B(a)P和多氯联苯混合物Aroclor 1254会引起MFO诱导。当鱼也暴露于水中溶解的芘、荧蒽和B(a)P时，B(a)P的生物累积导致MFO诱导，而芘和荧蒽的生物累积则不会。基于对B(a)P的水暴露和注射暴露，预测虹鳟鱼体内组织浓度超过300微克/千克B(a)P时会伴随MFO诱导。
