Unit Suicide Research & Mental Health Promotion, Department of Social and Preventive Medicine, Center for Public Health, Medical University of Vienna, Vienna, Austria.
Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Aust N Z J Psychiatry. 2020 Apr;54(4):409-422. doi: 10.1177/0004867419895112. Epub 2019 Dec 19.
Common mental disorders are strong risk factors for suicide attempt. We compared common mental disorder patients with and without suicide attempt regarding health care utilization and psychiatric medication, assessed gender differences and identified how psychotropic medication of attempters is associated with subsequent rehospitalization.
We used administrative claims data of 22,276 common mental disorder patients with inpatient care in Lower Austria between 1 January 2006 and 31 December 2011. Suicide attempters (cases, = 615) and non-attempters (controls, = 21,661) were compared regarding specific healthcare utilization by calculating mean differences of time-dependent contact probabilities and psychiatric medication (i.e. prescribed defined daily doses) ± 0.5 years around their suicide attempt (cases)/common mental disorder diagnosis (controls). Cluster analysis was used to group suicide attempters according to their psychiatric medication. The risk of rehospitalization 0.5-3 years after the attempt was calculated with regression analysis controlling for sex, age and morbidity-related factors.
Contacts with general practitioners were lower for attempters than non-attempters (mean difference of contact probabilities over observation period, males = -0.05, 95% confidence interval = [-0.07, -0.03]; females: mean difference = -0.04, 95% confidence interval = [-0.05, -0.03]). Regarding psychiatrists, female attempters had markedly higher contact probabilities after the attempt compared to female non-attempters (mean difference = 0.02, 95% confidence interval = [0.007, 0.04]); male attempters had lower contact probabilities before the attempt compared to male non-attempters (mean difference = -0.01, 95% confidence interval = [-0.004, -0.02]). Attempters had higher dosages of psychiatric medication across the entire period. Antidepressant and antipsychotic medication peaked at the time of common mental disorder diagnosis/attempt. Benzodiazepine prescriptions were considerably higher for male attempters than their female counterparts and were constantly elevated for male attempters across the observation period. A cluster of attempters with long-term benzodiazepine prescriptions had an increased risk of rehospitalization (adjusted odds ratio = 2.4, 95% confidence interval = [1.1, 5.5]).
Despite lower contact probabilities, common mental disorder patients with suicide attempt are prescribed more psychiatric medication, particularly benzodiazepines, with an elevated risk of rehospitalization. Strong sex differences were found.
常见精神障碍是自杀未遂的强烈危险因素。我们比较了有和没有自杀未遂的常见精神障碍患者的医疗保健利用和精神药物治疗情况,评估了性别差异,并确定了企图自杀者的精神药物治疗与随后的再住院之间的关系。
我们使用了 2006 年 1 月 1 日至 2011 年 12 月 31 日期间在奥地利下奥地利州接受住院治疗的 22276 例常见精神障碍患者的行政索赔数据。自杀未遂者(病例,615 例)和无自杀未遂者(对照,21661 例)在自杀未遂(病例)/常见精神障碍诊断(对照)前后 0.5 年左右的特定医疗保健利用情况方面进行了比较,通过计算时间依赖性接触概率和精神药物(即规定的日剂量)的平均值差异来评估。使用聚类分析根据精神药物治疗情况对自杀未遂者进行分组。使用回归分析控制性别、年龄和与发病相关的因素,计算自杀未遂后 0.5-3 年内的再住院风险。
与非自杀未遂者相比,自杀未遂者与全科医生的接触频率较低(观察期内接触概率的平均差异,男性=-0.05,95%置信区间=-0.07,-0.03;女性:平均差异=-0.04,95%置信区间=-0.05,-0.03)。对于精神科医生,女性自杀未遂者在尝试后与女性非自杀未遂者相比,接触概率明显更高(平均差异=0.02,95%置信区间=0.007,0.04);男性自杀未遂者在尝试前与男性非自杀未遂者相比,接触概率较低(平均差异=-0.01,95%置信区间=-0.004,-0.02)。整个时期内,自杀未遂者的精神药物剂量较高。抗抑郁药和抗精神病药在常见精神障碍诊断/尝试时达到峰值。与女性自杀未遂者相比,男性自杀未遂者的苯二氮䓬类药物处方明显更高,且在整个观察期间,男性自杀未遂者的苯二氮䓬类药物处方一直居高不下。长期使用苯二氮䓬类药物的自杀未遂者亚群再住院风险增加(调整后的优势比=2.4,95%置信区间=1.1,5.5)。
尽管接触概率较低,但有自杀未遂的常见精神障碍患者的精神药物处方更多,特别是苯二氮䓬类药物,再住院风险增加。发现了明显的性别差异。