Kofod Linette Marie, Hage Tine, Christiansen Lene Houmann, Skalkam Karin, Martinez Gerd, Godtfredsen Nina Skavlan, Molsted Stig
Physical Medicine and Rehabilitation Research - Copenhagen (PMR-C), Department of Physio- and Occupational Therapy, Copenhagen University Hospital, Hvidovre, Denmark.
Department of Physiotherapy, Copenhagen University Hospital, Nordsjælland, Denmark.
Eur Clin Respir J. 2019 Dec 9;7(1):1700086. doi: 10.1080/20018525.2019.1700086. eCollection 2020.
: It has been suggested that patients with inspiratory muscle weakness could benefit from specific inspiratory muscle training (IMT). We aimed to examine the frequency of patients with inspiratory muscle weakness in a Danish hospital-based outpatient pulmonary rehabilitation program, and to evaluate the association between inspiratory muscle strength and peripheral muscle strength and walking capacity. : Maximal Inspiratory Pressure (MIP) was assessed in 97 patients with COPD (39 men, 58 women, mean age years 70 ± 9, forced expiratory volume in 1 s ((FEV) = 35 ± 10% pred.). The impact of MIP on knee-extension strength, walking distance, and symptom burden was evaluated using multiple linear regression analyses. : The MIP of the patients with COPD was 63 (95% CI 59; 67) cmHO and it was significantly reduced compared to gender and age-matched reference values 76 (95% CI 73; 79) cmHO (p < 0.001). Seven patients (7.2%) were under the lower limit of normal. MIP was negatively correlated with increasing age, female gender, decreasing knee-extension strength and lower FEV% pred. Walking distance was associated with knee-extension strength and it was not associated with MIP. : Maximal inspiratory pressure was reduced in patients with COPD but only a few patients had a weak MIP. Whilst MIP was associated with leg muscle strength, it was not associated with walking distance or symptoms.
有人提出，吸气肌无力患者可能从特定的吸气肌训练（IMT）中获益。我们旨在调查丹麦一家医院门诊肺康复项目中吸气肌无力患者的比例，并评估吸气肌力量与外周肌肉力量及步行能力之间的关联。对97例慢性阻塞性肺疾病（COPD）患者（39名男性，58名女性，平均年龄70±9岁，第1秒用力呼气量（FEV1）=预计值的35±10%）进行了最大吸气压（MIP）评估。使用多元线性回归分析评估MIP对膝关节伸展力量、步行距离和症状负担的影响。COPD患者的MIP为63（95%可信区间59；67）cmH2O，与性别和年龄匹配的参考值76（95%可信区间73；79）cmH2O相比显著降低（p<0.001）。7例患者（7.2%）低于正常下限。MIP与年龄增加、女性性别、膝关节伸展力量降低以及较低的FEV1%预计值呈负相关。步行距离与膝关节伸展力量相关，与MIP无关。COPD患者的最大吸气压降低，但只有少数患者的MIP较弱。虽然MIP与腿部肌肉力量相关，但与步行距离或症状无关。
