Faculty of Veterinary Medicine, Department of Internal Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
Faculty of Veterinary Medicine, Department of Pharmacology-Toxicology, Hatay Mustafa Kemal University, Hatay, Turkey.
Arch Physiol Biochem. 2020 Dec;126(5):463-467. doi: 10.1080/13813455.2019.1702062. Epub 2019 Dec 19.
The aim of this study was to investigate hepatoprotective effect of some algae species such as sp. on experimental acute hepatotoxicity model that induced with carbon tetrachloride (CCl) in rats. Algaes at a dose of 200 mg/kg and Silymarin at a dose of 25 mg/kg were orally administered for 7 days followed by CCl at a single dose (0.5 ml/kg), at the 8th day to cause experimental acute hepatotoxicity. Levels of biochemical (AST, ALT etc.), lipid peroxidation (MDA), antioxidant (GSH, CAT, GPx) parameters and histopathological examination were carried out to investigate the hepatoprotective effects of algae. In Sp group ALT and ALP levels were significantly decreased compared with CCl ( < .05). Histological liver structures of Sp group were similar to the control group. MDA, GPx and CAT levels of Sp and La groups were significantly different compared with CCl ( < .05). Based on these results, algae species able to minimise the toxic effects of CCl and especially could be used in the purpose of protection against chemical-induced hepatotoxicity.
本研究旨在探讨几种藻类（如 sp.）对实验性急性肝毒性模型的肝保护作用，该模型是用四氯化碳（CCl）诱导大鼠产生的。藻类以 200mg/kg 的剂量和水飞蓟素以 25mg/kg 的剂量口服给药 7 天，然后在第 8 天给予单剂量（0.5ml/kg）的 CCl，以引起实验性急性肝毒性。进行生化（AST、ALT 等）、脂质过氧化（MDA）、抗氧化（GSH、CAT、GPx）参数和组织病理学检查，以研究藻类的肝保护作用。在 Sp 组中，与 CCl 相比，ALT 和 ALP 水平显著降低（<0.05）。Sp 组的肝组织学结构与对照组相似。Sp 和 La 组的 MDA、GPx 和 CAT 水平与 CCl 相比有显著差异（<0.05）。基于这些结果，能够最小化 CCl 毒性作用的藻类物种，特别是 sp.，可用于预防化学诱导的肝毒性。
