A Facile Preparation of Mussel-Inspired Poly(dopamine phosphonate-co-PEGMA)s via a One-Pot Multicomponent Polymerization System.

Mussel-inspired polymers attract much research interest due to their potential as effective adhesives. In this work, a new kind of mussel-inspired polymer, poly(dopamine phosphonate-co-PEGMA), is prepared via a one-pot multicomponent polymerization system. The multicomponent polymerization system refers to a combination of multicomponent Kabachnik-Fields (KF) reaction and reversible addition-fragmentation chain transfer (RAFT) polymerization system. Reactants are converted to dopamine phosphonate monomers in situ through the KF reaction and polymerized simultaneously along with poly(ethylene glycol methyl ether) methacrylate (PEGMA) co-monomers by the RAFT process in a one-pot operation. Target polymers with dopamine phosphonate as side groups and well-defined polymer structures are thus facilely and successfully prepared. Afterwards, a series of polymers with various ratios of dopamine phosphonates as well as the crosslinked polymer analogues are prepared. Benefiting from the dopamine phosphonate side groups, aqueous solutions of those polymers show potential as effective adhesives in both dry and wet conditions, and their adhesive strengths are highly related to ratios of dopamine phosphonates in the polymers. Those polymers are non-cytotoxic and show strong bonding affinities on various substrates including metals, polymers, and bovine bones, suggesting their potential as environmentally friendly general adhesives in broad areas.