Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, 621900, P. R. China.
The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Macromol Rapid Commun. 2020 Jan;41(2):e1900533. doi: 10.1002/marc.201900533. Epub 2019 Dec 19.
Mussel-inspired polymers attract much research interest due to their potential as effective adhesives. In this work, a new kind of mussel-inspired polymer, poly(dopamine phosphonate-co-PEGMA), is prepared via a one-pot multicomponent polymerization system. The multicomponent polymerization system refers to a combination of multicomponent Kabachnik-Fields (KF) reaction and reversible addition-fragmentation chain transfer (RAFT) polymerization system. Reactants are converted to dopamine phosphonate monomers in situ through the KF reaction and polymerized simultaneously along with poly(ethylene glycol methyl ether) methacrylate (PEGMA) co-monomers by the RAFT process in a one-pot operation. Target polymers with dopamine phosphonate as side groups and well-defined polymer structures are thus facilely and successfully prepared. Afterwards, a series of polymers with various ratios of dopamine phosphonates as well as the crosslinked polymer analogues are prepared. Benefiting from the dopamine phosphonate side groups, aqueous solutions of those polymers show potential as effective adhesives in both dry and wet conditions, and their adhesive strengths are highly related to ratios of dopamine phosphonates in the polymers. Those polymers are non-cytotoxic and show strong bonding affinities on various substrates including metals, polymers, and bovine bones, suggesting their potential as environmentally friendly general adhesives in broad areas.
受贻贝启发的聚合物由于其作为有效粘合剂的潜力而引起了广泛的研究兴趣。在这项工作中，通过一锅多组分聚合体系制备了一种新型的受贻贝启发的聚合物，即聚（多巴胺膦酸-co-PEGMA）。多组分聚合体系是指多组分 Kabachnik-Fields（KF）反应和可逆加成-断裂链转移（RAFT）聚合体系的组合。反应物通过 KF 反应原位转化为多巴胺膦酸单体，并通过 RAFT 过程在一锅操作中与聚（乙二醇甲基醚）甲基丙烯酸酯（PEGMA）共聚单体同时聚合。因此，轻松且成功地制备了具有多巴胺膦酸作为侧基和明确聚合物结构的目标聚合物。随后，制备了一系列具有不同比例多巴胺膦酸的聚合物以及交联聚合物类似物。得益于多巴胺膦酸侧基，这些聚合物在干燥和潮湿条件下的水溶液均显示出作为有效粘合剂的潜力，并且它们的粘合强度与聚合物中多巴胺膦酸的比例高度相关。这些聚合物无细胞毒性，并在包括金属、聚合物和牛骨在内的各种基质上表现出很强的结合亲和力，表明它们作为环保型通用粘合剂在广泛领域具有应用潜力。
