印度南部那加拉霍勒和班迪普尔森林地区莱姆病的血清流行率。
Seroprevalence of Lymes disease in the Nagarahole and Bandipur forest areas of South India.
机构信息
Department of Uveitis and Ocular Inflammation, Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India.
Department of Uveitis and Ocular Inflammation, Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Centre, Bengaluru; Department of Clinical Research, Institute of Bioinformatics, Bengaluru; Department of Clinical Research, Manipal Academy of Higher Education, Manipal, Karnataka, India.
出版信息
Indian J Ophthalmol. 2020 Jan;68(1):100-105. doi: 10.4103/ijo.IJO_943_19.
PURPOSE
The aim of this study was to determine the seroprevalence of Lymes disease in a population at risk in south India.
METHODS
Prospective ongoing study and included screening of forest workers and staff of Nagarahole and Bandipur forest ranges in South India for Lymes disease. Screening included a detailed questionnaire for Lymes disease, complete ocular and systemic examination by an ophthalmologist and infectious disease specialist and blood collection. ELISA for IgM and IgG antibodies for Borrelia burgdorferi were performed on the collected sera samples. Western blot confirmation was done on the seropositive samples. Ticks were also collected from these forest areas for future studies to detect if they harbor B. burgdorferi.
RESULTS
Seroprevalence of 19.9% was noted by ELISA. Western blot confirmation was seen in 15.6% of the seropositive samples. There was significant correlation between seropositivity and exposure to tick bites (P = 0.023).
CONCLUSION
There is a high seroprevalence of infection with B. burgdorferi in the forest areas of Nagarahole and Bandipur ranges in south India.
目的
本研究旨在确定印度南部高危人群莱姆病的血清流行率。
方法
对印度南部纳加拉霍尔和班迪普尔森林地区的森林工作者和工作人员进行莱姆病的前瞻性持续研究和筛查。筛查包括莱姆病详细问卷、眼科医生和传染病专家进行的全面眼部和全身检查以及血液采集。对采集的血清样本进行针对伯氏疏螺旋体的 IgM 和 IgG 抗体的 ELISA 检测。对血清阳性样本进行 Western blot 确认。还从这些森林地区采集了蜱虫，以进行未来的研究，以检测它们是否携带伯氏疏螺旋体。
结果
ELISA 检测到的血清流行率为 19.9%。Western blot 确认在 15.6%的血清阳性样本中可见。血清阳性与接触蜱叮咬之间存在显著相关性（P=0.023）。
结论
印度南部纳加拉霍尔和班迪普尔地区的森林地区存在伯氏疏螺旋体感染的高血清流行率。
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