结构化运动计划对慢性疲劳综合征患者认知功能的影响
The Impact of a Structured Exercise Programme upon Cognitive Function in Chronic Fatigue Syndrome Patients.
作者信息
Zalewski Paweł, Kujawski Sławomir, Tudorowska Malwina, Morten Karl, Tafil-Klawe Małgorzata, Klawe Jacek J, Strong James, Estévez-López Fernando, Murovska Modra, Newton Julia L
机构信息
Department of Hygiene, Epidemiology and Ergonomics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
Gizińscy Medical Centre, Kościuszki 16, 85-079 Bydgoszcz, Poland.
出版信息
Brain Sci. 2019 Dec 19;10(1):4. doi: 10.3390/brainsci10010004.
BACKGROUND
Cognitive function disturbance is a frequently described symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, the effects of a structured exercise programme (SEP) upon cognitive function in ME/CFS patients was examined.
METHODS
Out of the 53 ME/CFS patients initiating SEP 34 (64%) completed the 16 week programme. Cognitive function was assessed using a computerized battery test consisting of a Simple Reaction Time (SRT) (repeated three times) and Choice Reaction Time (CRT) measurements, a Visual Attention Test (VAT) and a Delayed Matching to Sample (DMS) assessment.
RESULTS
Statistically significant improvement was noted in the third attempt to SRT in reaction time for correct answers, = 0.045, r = 0.24. Moreover, significant improvement was noted in VAT reaction time, number of correct answers and errors committed, = 0.02, omega = 0.03, = 0.007, r = 0.34 and = 0.004, r = 0.35, respectively. Non-significant changes were noted in other cognitive tests.
CONCLUSIONS
A substantial number of participants were unwilling or unable to complete the exercise programme. ME/CFS patients able to complete the SEP showed improved visual attention both in terms of reaction time and correctness of responses and processing speed of simple visual stimuli.
背景
认知功能障碍是肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）中经常描述的一种症状。在本研究中，研究了结构化运动计划（SEP）对ME/CFS患者认知功能的影响。
方法
在开始SEP的53例ME/CFS患者中，34例（64%）完成了为期16周的计划。使用计算机化综合测试评估认知功能，该测试包括简单反应时间（SRT）（重复三次）和选择反应时间（CRT）测量、视觉注意力测试（VAT）和延迟匹配样本（DMS）评估。
结果
在正确答案的SRT第三次尝试中，反应时间有统计学意义的改善，P = 0.045，r = 0.24。此外，VAT反应时间、正确答案数量和错误数量也有显著改善，P分别为0.02、ω = 0.03、P = 0.007，r = 0.34和P = 0.004，r = 0.35。在其他认知测试中未发现显著变化。
结论
大量参与者不愿意或无法完成运动计划。能够完成SEP的ME/CFS患者在反应时间、反应正确性和简单视觉刺激的处理速度方面均表现出视觉注意力的改善。
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