Kujawski Sławomir, Cossington Jo, Słomko Joanna, Zawadka-Kunikowska Monika, Tafil-Klawe Małgorzata, Klawe Jacek J, Buszko Katarzyna, Jakovljevic Djordje G, Kozakiewicz Mariusz, Morten Karl J, Dawes Helen, Strong James W L, Murovska Modra, Van Oosterwijck Jessica, Estevez-Lopez Fernando, Newton Julia L, Hodges Lynette, Zalewski Paweł
Department of Hygiene, Epidemiology, Ergonomy and Postgraduate Education, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
Centre for Movement Occupational and Rehabilitation Sciences, Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Headington Rd, Headington, Oxford OX3 0BP, UK.
J Clin Med. 2021 Apr 6;10(7):1542. doi: 10.3390/jcm10071542.
The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters.
Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VOpeak, VOsubmax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT).
Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels ( = 0.002 and = 0.00005, respectively). The relationships between VO peak and Mfn1 increase in response to IAP ( = 0.03) and between VO at anaerobic threshold and ANS response to the HUTT ( = 0.03) were noted.
It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.
近期，结构化活动计划中的运动治疗效果受到质疑；因此，本研究探讨个性化活动计划（IAP）对心血管、线粒体和疲劳参数之间关系的影响。
使用查尔德疲劳问卷（CFQ）、疲劳严重程度评分（FSS）和疲劳影响量表（FIS）对慢性疲劳综合征（CFS）患者进行评估。通过心肺运动试验评估最大摄氧量（VOpeak）、次最大摄氧量（VOsubmax）和心率（HR）。评估血浆中Mfn1和Mfn2水平。使用任务组监测仪评估仰卧休息时以及对直立倾斜试验（HUTT）的自主神经系统功能。
34名患者完成了16周的IAP。CFQ、FSS和FIS评分显著降低，同时Mfn1和Mfn2水平显著升高（分别为 = 0.002和 = 0.00005）。注意到IAP后最大摄氧量与Mfn1增加之间的关系（ = 0.03）以及无氧阈值时的摄氧量与自主神经系统对HUTT的反应之间的关系（ = 0.03）。
得出结论，IAP可减轻疲劳并改善功能表现，同时自主神经和线粒体功能也会发生变化。然而，必须谨慎，因为51%的患者对运动耐受性不佳。
