School of Medicine and Surgery, University of Milano-Bicocca, Italy.
Yozgat Bozok University, Medical Faculty, Turkey.
Mech Ageing Dev. 2020 Jan;185:111197. doi: 10.1016/j.mad.2019.111197. Epub 2019 Dec 17.
With more than 80 subunits, potassium (K) channels represent a group of ion channels showing high degree of diversity and ubiquity. They play important role in the control of membrane depolarization and cell excitability in several tissues, including the brain. Controlling the intracellular and extracellular K flow in cells, they also modulate the hormone and neurotransmitter release, apoptosis and cell proliferation. It is therefore not surprising that an improper functioning of K channels in neurons has been associated with pathophysiology of a wide range of neurological disorders, especially Alzheimer's disease (AD). This review aims to give a comprehensive overview of the basic properties and pathophysiological functions of the main classes of K channels in the context of disease processes, also discussing the progress, challenges and opportunities to develop drugs targeting these channels as potential pharmacological approach for AD treatment.
钾 (K) 通道有超过 80 种亚基，是一组具有高度多样性和普遍性的离子通道。它们在包括大脑在内的多种组织中对膜去极化和细胞兴奋性的控制中发挥重要作用。通过控制细胞内外的 K 流，它们还调节激素和神经递质的释放、细胞凋亡和增殖。因此，神经元中 K 通道的异常功能与广泛的神经退行性疾病（尤其是阿尔茨海默病）的病理生理学有关也就不足为奇了。这篇综述旨在全面概述主要类型 K 通道在疾病过程中的基本特性和病理生理功能，同时讨论针对这些通道开发药物的进展、挑战和机遇，作为治疗 AD 的潜在药理学方法。
