Yao Jiafeng, Wang Li, Liu Kai, Wu Hongtao, Wang Hao, Huang Jingshi, Li Jianping
College of Mechanical & Electrical Engineering, Nanjing University of Aeronautics & Astronautics, Nanjing, P. R. China.
Institute of Otolaryngology, Guangzhou No.12 Hospital, Guangzhou, P. R. China.
Electrophoresis. 2020 Sep;41(16-17):1425-1432. doi: 10.1002/elps.201900420. Epub 2020 Jan 9.
The electrical characteristics of biological tissue is evaluated by establishing an electrical equivalent circuit with electrical impedance spectroscopy. The least squares method is used to realize electrical equivalent circuit fitting by using the developed portable electrical impedance spectroscopy system. The EIS system is used to obtain the impedance spectrum data of the measured biological tissue. In the experiment, the impedance spectrum data of eggs under different heating time were measured, and the established equivalent circuit model of eggs was fitted by nonlinear least squares fitting algorithm. Moreover, the electrical characteristics of the biological tissue are also revealed by numerical simulation with HANAI model. The experimental and simulation results show that the extracted equivalent electrical parameters can clearly characterize the variation of the internal change of components of biological tissues.
通过用电阻抗谱建立等效电路来评估生物组织的电学特性。利用所开发的便携式电阻抗谱系统,采用最小二乘法实现等效电路拟合。电阻抗谱系统用于获取被测生物组织的阻抗谱数据。在实验中,测量了不同加热时间下鸡蛋的阻抗谱数据,并通过非线性最小二乘拟合算法对所建立的鸡蛋等效电路模型进行拟合。此外,还利用HANAI模型通过数值模拟揭示了生物组织的电学特性。实验和模拟结果表明,所提取的等效电学参数能够清晰地表征生物组织内部成分变化的情况。