The Institute of Precision Machinery and Smart Structure, College of Engineering, Zhejiang Normal University, Jinhua 321004, China.
Graduate School of Mechanical Engineering, Division of Artificial System Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
Sensors (Basel). 2021 Feb 21;21(4):1496. doi: 10.3390/s21041496.
A quantitative and rapid burn injury detection method has been proposed based on the electrical impedance spectroscopy (EIS) of blood with a seven-parameter equivalent circuit. The degree of burn injury is estimated from the electrical impedance characteristics of blood with different volume proportions of red blood cells (RBCs) and heated red blood cells (HRBCs). A quantitative relationship between the volume portion of HRBCs and the electrical impedance characteristics of blood has been demonstrated. A seven -parameter equivalent circuit is employed to quantify the relationship from the perspective of electricity. Additionally, the traditional Hanai equation has been modified to verify the experimental results. Results show that the imaginary part of impedance under the characteristic frequency () has a linear relationship with which could be described by = -2.56 - 2.01 with a correlation coefficient of 0.96. Moreover, the relationship between the plasma resistance and is obtained as = -7.2 + 3.91 with a correlation coefficient of 0.96 from the seven -parameter equivalent circuit. This study shows the feasibility of EIS in the quantitative detection of burn injury by the quantitative parameters and , which might be meaningful for the follow-up clinical treatment for burn injury.
基于血液的电阻抗谱（EIS）和一个七参数等效电路，提出了一种定量且快速的烧伤检测方法。通过测量不同红细胞（RBC）和加热红细胞（HRBC）体积比例下的血液电阻抗特性，来估计烧伤程度。证明了 HRBC 体积与血液电阻抗特性之间存在定量关系。采用七参数等效电路从电学角度定量描述这种关系。此外，还对传统的 Hanai 方程进行了修正，以验证实验结果。结果表明，特征频率（）下的阻抗虚部（）与呈线性关系，可以用= -2.56 - 2.01 来描述，相关系数为 0.96。此外，从七参数等效电路中得到血浆电阻（）与的关系为= -7.2 + 3.91，相关系数为 0.96。本研究通过定量参数和 ，展示了 EIS 在烧伤定量检测中的可行性，这可能对烧伤后续的临床治疗具有重要意义。
