Covert R F, Drummond W H, Webb I B, Gimotty P A
Department of Pediatrics, University of Florida College of Medicine, Gainesville.
Pediatr Cardiol. 1988;9(3):137-41. doi: 10.1007/BF02080553.
Promethazine is an antihistamine commonly used for sedation in clinical pediatric medicine. We studied the cardiovascular effects of promethazine in normoxic, conscious, chronically instrumented neonatal lambs. Eight lambs received 1.3 mg/kg of promethazine intravenously (i.v.) while at rest. In all lambs, promethazine led to elevations of pulmonary vascular resistance, mean pulmonary arterial pressure, mean transpulmonary pressure, mean left atrial pressure, and the ratio of pulmonary-to-systemic vascular resistance. In addition, five (63%) of the lambs demonstrated an increase in mean systemic arterial pressure and systemic vascular resistance to promethazine. A subgroup of three lambs, which tended to be younger, failed to demonstrate the systemic vascular response to promethazine. Promethazine given i.v. has important cardiovascular effects. We hypothesize that promethazine used for sedation before cardiac catheterization in children may alter subsequent hemodynamic observations.
异丙嗪是临床儿科学中常用于镇静的一种抗组胺药。我们研究了异丙嗪对常氧、清醒、长期植入监测装置的新生羔羊的心血管效应。八只羔羊在静息状态下静脉注射1.3mg/kg异丙嗪。在所有羔羊中，异丙嗪导致肺血管阻力、平均肺动脉压、平均跨肺压、平均左心房压以及肺血管阻力与体循环血管阻力之比升高。此外，五只（63%）羔羊对异丙嗪的平均体循环动脉压和体循环血管阻力增加。一组三只年龄较小的羔羊亚组未表现出对异丙嗪的体循环血管反应。静脉注射异丙嗪具有重要的心血管效应。我们推测，儿童在心脏导管插入术前用于镇静的异丙嗪可能会改变随后的血流动力学观察结果。
