Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Department of Internal Medicine, University of Minnesota, Minneapolis, MN, USA.
Obes Surg. 2020 Apr;30(4):1459-1467. doi: 10.1007/s11695-019-04332-2.
Laparoscopic sleeve gastrectomy (LSG) is a commonly performed bariatric surgery. Studies have suggested that LSG can provide effective and sustainable weight loss although most of them were conducted in Western populations. Our aim was to characterize the midterm outcome of LSG in Asians with obesity.
MEDLINE and EMBASE were searched through August 2019 for studies that reported % total body weight loss (TBWL) and/or % excess weight loss (EWL) at 3 and/or 5 years among adult Asians with obesity who underwent LSG. Data on complications and surgical revision rate were also extracted. The pooled effect size and 95% confidence interval (CI) were calculated using a random effects model.
A total of 19 studies involving 6235 patients were included. The pooled mean %EWLs were 72.6% (95% CI 67.2-78.0, I = 97%); 67.1% (95% CI 61.7-72.6, I = 95%); and 59.1% (95% CI 48.8-69.4, I = 94%) at 1, 3, and 5 years, respectively. The pooled mean %TBWLs were 32.1%, 29.0%, and 25.5% at 1, 3, and 5 years, respectively. The pooled rates of revision due to gastroesophageal reflux disease and weight regain were 1.9% and 2.5%, respectively.
Our meta-analysis suggests that LSG is an effective procedure for weight reduction that offers durable response for up to 5 years among Asians with obesity. The longer-term data is needed.
腹腔镜袖状胃切除术（LSG）是一种常见的减肥手术。虽然大多数研究都是在西方人群中进行的，但研究表明 LSG 可以提供有效的、可持续的减重效果。我们的目的是分析亚洲肥胖人群接受 LSG 后的中期结果。
通过 MEDLINE 和 EMBASE 检索 2019 年 8 月之前的研究，这些研究报告了接受 LSG 的亚洲肥胖成年人在 3 年和/或 5 年后的总体重减轻百分比（TBWL）和/或超重减轻百分比（EWL）。还提取了并发症和手术修正率的数据。使用随机效应模型计算合并效应大小和 95%置信区间（CI）。
共纳入 19 项研究，共 6235 例患者。汇总的平均 EWL 百分比分别为 72.6%（95%CI 67.2-78.0，I=97%）；67.1%（95%CI 61.7-72.6，I=95%）；59.1%（95%CI 48.8-69.4，I=94%）在 1、3 和 5 年时。汇总的平均 TBWL 百分比分别为 32.1%、29.0%和 25.5%，在 1、3 和 5 年时。因胃食管反流病和体重反弹而进行修正的比例分别为 1.9%和 2.5%。
我们的荟萃分析表明，LSG 是一种有效的减肥手术，在亚洲肥胖人群中，5 年内减重效果持久。需要更长时间的数据。
