Horsmanheimo M, Krohn K, Virolainen M
J Invest Dermatol. 1977 Jan;68(1):10-5. doi: 10.1111/1523-1747.ep12485128.
This report describes the clinical improvement and acquisition of tuberculin skin-test sensitivity by a tuberculin-negative, drug-resistant patient with lupus vulgaris after a single injection of dialyzable transfer factor (TFd) from a tuberculin-positive healthy donor. The patient's lymphocytes showed a slight response to tuberculin in the leukocyte migration inhibition test and in the lymphocyte transformation test before TFd injection. The acquisition of cellular immunity to tuberculin was demonstrated in vitro by enhanced tuberculin-induced blast transformation. A good correlation between skin test and in vitro tuberculin sensitivity and clinical improvement was seen during the three years that the patient was observed.
本报告描述了一名狼疮寻常型结核菌素阴性的耐药患者，在单次注射来自结核菌素阳性健康供体的可透析转移因子（TFd）后，临床症状改善及结核菌素皮肤试验敏感性的获得情况。在注射TFd之前，患者的淋巴细胞在白细胞游走抑制试验和淋巴细胞转化试验中对结核菌素显示出轻微反应。通过增强结核菌素诱导的母细胞转化在体外证实了对结核菌素细胞免疫的获得。在观察该患者的三年期间，皮肤试验与体外结核菌素敏感性及临床改善之间呈现出良好的相关性。
