Precision Health Economics, Los Angeles, California, USA.
Novo Nordisk Inc., Plainsboro, New Jersey, USA.
Obesity (Silver Spring). 2020 Feb;28(2):429-436. doi: 10.1002/oby.22696. Epub 2019 Dec 23.
Obesity and its complications place an enormous burden on society. Yet antiobesity medications (AOM) are prescribed to only 2% of the eligible population, even though few individuals can sustain weight loss using other strategies alone. This study estimated the societal value of greater access to AOM.
By using a well-established simulation model (The Health Economics Medical Innovation Simulation), the societal value of AOM for the cohort of Americans aged ≥ 25 years in 2019 was quantified. Four scenarios with differential uptake among the eligible population (15% and 30%) were modeled, with efficacy from current and next-generation AOM. Societal value was measured as monetized quality of life, productivity gains, and savings in medical spending, subtracting the costs of AOM.
For the 217 million Americans aged ≥ 25 years, AOM generated $1.2 trillion in lifetime societal value under a conservative scenario (15% annual uptake using currently available AOM). The introduction of next-generation AOM increased societal value to $1.9 to $2.5 trillion, depending on uptake. Finally, societal value was higher for younger individuals and Black and Hispanic individuals compared with White individuals.
This study suggests that AOM provide substantial gains to patients and society. Policies promoting broader clinical access to and use of AOM warrant consideration to reach national goals to reduce obesity.
肥胖及其并发症给社会带来了巨大负担。然而，只有 2%的符合条件的人群接受了抗肥胖药物（AOM）治疗，尽管很少有人仅通过其他策略就能维持体重减轻。本研究旨在评估增加 AOM 可及性的社会效益。
本研究使用了一种经过充分验证的模拟模型（The Health Economics Medical Innovation Simulation），对 2019 年美国≥25 岁人群中 AOM 的社会效益进行了量化。通过模拟符合条件人群中（15%和 30%）不同的吸收率，以及当前和下一代 AOM 的疗效，建立了四个不同的情景。社会效益通过货币化的生活质量、生产力提高和医疗支出节省来衡量，减去 AOM 的成本。
对于 2.17 亿美国≥25 岁的人群，在保守情景下（每年有 15%的人使用现有的 AOM），AOM 带来了 1.2 万亿美元的终生社会效益。引入下一代 AOM 将社会效益提高到 1.9 万亿美元至 2.5 万亿美元，具体取决于吸收率。最后，与白人相比，年轻人、黑人和西班牙裔人群的社会效益更高。
本研究表明，AOM 为患者和社会带来了巨大的收益。为了实现减少肥胖的国家目标，应考虑制定促进更广泛地临床应用 AOM 的政策。
