Riboli E, Péquignot G, Repetto F, Axerio M, Raymond L, Boffetta P, Zubiri A, Del Moral A, Estève J, Tuyns A J
International Agency for Research on Cancer, Lyon, France.
Rev Epidemiol Sante Publique. 1988;36(3):151-65.
Diet, tobacco and alcohol consumption, and occupational histories have been investigated in stratified random samples of the adult population in 6 areas in France (departement of Calvados), Italy (province of Varese and city of Torino), Spain (provinces of Navarra and Zaragoza) and Switzerland (canton of Geneva), to be used as a reference group in a case-control study on cancer of the larynx and hypopharynx. Out of a total of 8,074 sampled subjects, 5,564 could be interviewed. Sampling procedures are described, and reasons for non-response are analysed. Everywhere the intake of the 4 energy providing nutrients (particularly alcohol) was much greater in men than in women. In both sexes, total caloric intake was higher in Calvados and in Italy than elsewhere. There were wide inter-area variations in the consumption of butter + milk products and oils, resulting in a polyunsaturated/saturated fatty acid ratio ranging from 0.27 in Calvados to 0.54-0.65 in Spain. Among nutrients suggested to be involved in cancer aetiology, inter-area differences in daily intake were up to 3-fold for carotene and smaller for vitamin C and fibre. The proportion of lipids, fibres, vitamin C and carotene provided by different foods varied widely between areas, thus suggesting that in etiological cancer studies consideration should be given not only to nutrients but also to foods providing them.
在法国(卡尔瓦多斯省)、意大利(瓦雷泽省和都灵市)、西班牙(纳瓦拉省和萨拉戈萨省)和瑞士(日内瓦州)的6个地区,对成年人群分层随机样本的饮食、烟草和酒精消费以及职业经历进行了调查,以便在一项关于喉癌和下咽癌的病例对照研究中作为参照组。在总共8074名抽样对象中,5564人接受了访谈。文中描述了抽样程序,并分析了无应答原因。各地男性摄入的4种供能营养素(尤其是酒精)均远多于女性。在男女两性中,卡尔瓦多斯省和意大利的总热量摄入高于其他地区。黄油+奶制品和油类的消费量在各地区之间存在很大差异,导致多不饱和/饱和脂肪酸比例从卡尔瓦多斯省的0.27到西班牙的0.54 - 0.65不等。在被认为与癌症病因有关的营养素中,不同地区每日摄入量的差异,胡萝卜素高达3倍,维生素C和纤维则较小。不同食物提供的脂质、纤维、维生素C和胡萝卜素比例在各地区之间差异很大,因此表明在癌症病因学研究中,不仅应考虑营养素,还应考虑提供这些营养素的食物。