Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Huddinge, 14104, Sweden.
Division of Endodontics, Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh, 11545, Saudi Arabia.
Proteomics Clin Appl. 2020 May;14(3):e1900039. doi: 10.1002/prca.201900039. Epub 2020 Jan 17.
Salivary proteins have an imperative role in the maintenance of oral health and repairing mechanisms of injured tissues. However, there is paucity of information reported in the literature about the influence of chewing activities on the secretion or expression of salivary proteins. The purpose of this systematic review is to evaluate the effect of chewing on the expression of salivary proteins composition in healthy individuals. A thorough systematic search shows 14 eligible studies for the review. The results of the systematic review show the effect of chewing on total protein concentration, alpha-amylase (α-amylase), peroxidase, lysozyme, immunoglobulin A (IgA), and mucin. Six papers concluded that chewing has a little or no effect on total protein concentration, α-amylase, peroxidase, lysozyme, and IgA activities. Five papers reported a negative (decreasing) effect of chewing on the function of total protein, α-amylase, IgA, and mucin. Only two papers showed an increase in total protein and IgA function upon chewing stimulation. The results of this systematic review indicate that more standardized evidence-based research is required for better assessment of chewing effects on salivary proteins. Within the limitations of this review, the existing evidence suggests that chewing in healthy people has minimum effect on the expression and activities of salivary proteins.
唾液蛋白在维护口腔健康和修复受损组织的机制中起着至关重要的作用。然而，关于咀嚼活动对唾液蛋白分泌或表达的影响，文献中报道的信息很少。本系统评价的目的是评估咀嚼对健康个体唾液蛋白组成表达的影响。彻底的系统搜索显示，有 14 项符合条件的研究纳入了本综述。系统评价的结果表明，咀嚼对总蛋白浓度、α-淀粉酶（α-淀粉酶）、过氧化物酶、溶菌酶、免疫球蛋白 A（IgA）和粘蛋白有影响。六篇论文得出结论，咀嚼对总蛋白浓度、α-淀粉酶、过氧化物酶、溶菌酶和 IgA 活性几乎没有影响。五篇论文报告说，咀嚼对总蛋白、α-淀粉酶、IgA 和粘蛋白的功能有负（降低）影响。只有两篇论文显示咀嚼刺激后总蛋白和 IgA 功能增加。本系统评价的结果表明，需要更多基于标准化证据的研究来更好地评估咀嚼对唾液蛋白的影响。在本综述的限制范围内，现有证据表明，健康人咀嚼对唾液蛋白的表达和活性影响最小。
