Alm Kylie H, Faria Andreia V, Moghekar Abhay, Pettigrew Corinne, Soldan Anja, Mori Susumu, Albert Marilyn, Bakker Arnold
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD.
Neurobiol Aging. 2020 Mar;87:78-88. doi: 10.1016/j.neurobiolaging.2019.11.011. Epub 2019 Nov 21.
Significant evidence demonstrates that aging is associated with variability in cognitive performance, even among individuals who are cognitively normal. In this study, we examined measures from magnetic resonance imaging and cerebrospinal fluid (CSF) to investigate which measures, alone or in combination, were associated with individual differences in episodic memory performance. Using hierarchical linear regressions, we compared the ability of diffusion tensor imaging (DTI) metrics, CSF measures of amyloid and tau, and gray matter volumes to explain variability in memory performance in a cohort of cognitively normal older adults. Measures of DTI microstructure were significantly associated with variance in memory performance, even after accounting for the contribution of the CSF and magnetic resonance imaging gray matter volume measures. Significant associations were found between DTI measures of the hippocampal cingulum and fornix with individual differences in memory. No such relationships were found between memory performance and CSF markers or gray matter volumes. These findings suggest that DTI metrics may be useful in identifying changes associated with aging or age-related diseases.
大量证据表明，衰老与认知能力的变异性有关，即使在认知正常的个体中也是如此。在本研究中，我们检查了磁共振成像和脑脊液（CSF）的测量指标，以调查哪些指标单独或联合使用与情景记忆表现的个体差异相关。使用分层线性回归，我们比较了扩散张量成像（DTI）指标、淀粉样蛋白和tau的脑脊液测量指标以及灰质体积解释认知正常的老年人队列中记忆表现变异性的能力。即使在考虑了脑脊液和磁共振成像灰质体积测量指标的贡献后，DTI微观结构测量指标仍与记忆表现的差异显著相关。在海马扣带和穹窿的DTI测量指标与记忆的个体差异之间发现了显著关联。在记忆表现与脑脊液标志物或灰质体积之间未发现此类关系。这些发现表明，DTI指标可能有助于识别与衰老或年龄相关疾病相关的变化。
