Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Ann Epidemiol. 2020 Jan;41:49-55. doi: 10.1016/j.annepidem.2019.11.005. Epub 2019 Nov 30.
To examine the age, period, and cohort effects on asthma prevalence among Canadian adults from 1994/1995 to 2010/2011.
Using data from the National Population Health Survey, 13,616 Canadian adults were followed for 16 years. Age was limited to 18-80 years during follow-up. Modified Poisson regression models with generalized estimating equations were used to estimate age, period, and cohort effects on asthma and active asthma prevalence after accounting for sociodemographic factors. Model-based standardization was performed to estimate standardized rates.
Overall asthma prevalence increased from 5% in 1994/1995 to 11% in 2010/2011; decreasing from 12% for 20-year-olds to 6% for 50-60-year-olds and then increased to 8% for 80-year-olds. Individuals aged 20 years had the steepest increase in prevalence between 1994/1995 and 2010/2011. Active asthma prevalence increased from 5% in 1994/1995 to 8% in 2010/2011; decreasing from 8% for 20-year-olds to 5% for 50-60-year-olds and then increased to 6% for 80-year-olds.
Our findings suggest the presence of age, period, and cohort effects on prevalence of asthma overall and presence of age and period effects on active asthma prevalence in Canadian adults.
研究 1994/1995 年至 2010/2011 年期间加拿大成年人哮喘患病率的年龄、时期和队列效应。
利用全国人口健康调查的数据，对 13616 名加拿大成年人进行了 16 年的随访。随访期间年龄限制在 18-80 岁。采用广义估计方程的修正泊松回归模型，在考虑社会人口因素的基础上，估计哮喘和活动性哮喘患病率的年龄、时期和队列效应。进行基于模型的标准化，以估计标准化率。
总体而言，哮喘患病率从 1994/1995 年的 5%上升到 2010/2011 年的 11%；从 20 岁人群的 12%下降到 50-60 岁人群的 6%，然后上升到 80 岁人群的 8%。20 岁人群的患病率在 1994/1995 年至 2010/2011 年之间增长最为显著。活动性哮喘患病率从 1994/1995 年的 5%上升到 2010/2011 年的 8%；从 20 岁人群的 8%下降到 50-60 岁人群的 5%，然后上升到 80 岁人群的 6%。
我们的研究结果表明，年龄、时期和队列效应对加拿大成年人哮喘总体患病率以及年龄和时期效应对活动性哮喘患病率有影响。
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