槲皮素、没食子儿茶素没食子酸酯、姜黄素和白藜芦醇：从膳食来源到人类 microRNA 调节。
Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation.
机构信息
Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Edificio Polifunzionale, 87036 Rende (CS), Italy.
Department of Health Science, School of Medicine, University of Magna Graecia, Clinical Pharmacology Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
出版信息
Molecules. 2019 Dec 23;25(1):63. doi: 10.3390/molecules25010063.
Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well-known capability of these molecules to act as antioxidants, they are able to interact with cell-signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.
流行病学研究表明，饮食中的多酚摄入与几种非传染性疾病的发病率降低有关。虽然几种食物含有复杂的多酚混合物，但许多因素会影响它们的含量。除了这些分子作为抗氧化剂的众所周知的能力外，它们还能够与细胞信号通路相互作用，调节基因表达，影响转录因子的活性，并调节 microRNAs。在这里，我们深入描述了四种用作营养补充剂的多酚：槲皮素、白藜芦醇、表没食子儿茶素没食子酸酯（EGCG）和姜黄素，总结了关于它们的当前知识，从饮食来源到这些化合物对 microRNA 调节的表观遗传能力。
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