Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 81371 Bratislava, Slovakia.
Molecules. 2020 Jul 22;25(15):3322. doi: 10.3390/molecules25153322.
Numerous studies document an increased production of reactive oxygen species (ROS) with a subsequent decrease in nitric oxide (NO) bioavailability in different cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. Many natural polyphenols have been demonstrated to decrease ROS generation and/or to induce the endogenous antioxidant enzymatic defense system. Moreover, different polyphenolic compounds have the ability to increase the activity/expression of endothelial nitric oxide synthase (eNOS) with a subsequent enhancement of NO generation. However, as a result of low absorption and bioavailability of natural polyphenols, the beneficial effects of these substances are very limited. Recent progress in delivering polyphenols to the targeted tissues revealed new possibilities for the use of polymeric nanoparticles in increasing the efficiency and reducing the degradability of natural polyphenols. This review focuses on the effects of different natural polyphenolic substances, especially resveratrol, quercetin, curcumin, and cherry extracts, and their ability to bind to polymeric nanoparticles, and summarizes the effects of polyphenol-loaded nanoparticles, mainly in the cardiovascular system.
许多研究表明，在包括高血压、动脉粥样硬化和心力衰竭在内的不同心血管疾病中，活性氧（ROS）的产生增加，而一氧化氮（NO）的生物利用度降低。许多天然多酚已被证明可减少 ROS 的产生和/或诱导内源性抗氧化酶防御系统。此外，不同的多酚化合物具有增加内皮型一氧化氮合酶（eNOS）活性/表达的能力，从而增强 NO 的生成。然而，由于天然多酚吸收和生物利用度低，这些物质的有益作用非常有限。最近在将多酚递送到靶向组织方面取得的进展为利用聚合物纳米粒子提高天然多酚的效率和降低其降解性提供了新的可能性。本文重点介绍了不同天然多酚物质（特别是白藜芦醇、槲皮素、姜黄素和樱桃提取物）的作用及其与聚合物纳米粒子结合的能力，并总结了多酚负载纳米粒子的作用，主要在心血管系统中。
