Department of Urology, University of Catania, 95125 Catania, Italy.
Oxid Med Cell Longev. 2012;2012:632959. doi: 10.1155/2012/632959. Epub 2012 May 28.
Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.
前列腺癌是最常见的实体肿瘤，现在被认为是男性面临的最重要的医学问题之一。由于其潜伏期长且存在可识别的癌前病变，前列腺癌是化学预防的理想靶肿瘤。有不同的化合物可用，多酚类化合物肯定是具有抗前列腺癌作用的化合物。本综述着眼于主要多酚类物质的活性和特性，如表没食子儿茶素-3-没食子酸酯、姜黄素、白藜芦醇以及类黄酮槲皮素和染料木黄酮。尽管目前的研究有限，但多酚类化合物的作用机制加上缺乏副作用表明，前列腺癌化学预防的未来策略有了一个开始。
