Zhang Jinxuan, Luo Jianquan, Ren Zhongyuan, Zhang Hao, Chen Xiangrong, Wan Yinhua
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Beijing 100190, China.
Sheng Wu Gong Cheng Xue Bao. 2019 Dec 25;35(12):2257-2268. doi: 10.13345/j.cjb.190229.
Membrane creates the functions of protection, supporting, dispersion and separation. More functions can be designed by modifying membrane surface and grafting/loading selective ligands or catalysts on the membrane, thus membrane technology has been widely applied in biological detection, and its application approaches becomes diverse. Rational design of functional membranes can meet the demands in different steps of biological detection process, including sample pretreatment, preparation, response and sensing. This review summarized the functionalization methods of filtration membranes, applications of membrane technology in sample preparation and detection process, as well as the research on the integration of functional membranes. By revisiting the research progress on functional membrane design, preparation and applications for biological detection, it is expected to take better advantage of membrane materials structure and performance for constructing efficient and stable detection platform, which is more "adapted" to the detection environment.
膜具有保护、支撑、分散和分离等功能。通过修饰膜表面以及在膜上接枝/负载选择性配体或催化剂，可以设计出更多功能，因此膜技术已广泛应用于生物检测领域，其应用方式也日益多样。功能膜的合理设计能够满足生物检测过程不同步骤的需求，包括样品预处理、制备、响应和传感。本文综述了过滤膜的功能化方法、膜技术在样品制备和检测过程中的应用，以及功能膜集成方面的研究。通过回顾功能膜用于生物检测的设计、制备及应用方面的研究进展，有望更好地利用膜材料的结构和性能构建高效稳定的检测平台，使其更“适配”检测环境。
