Luo Jianquan, Song Siqing, Zhang Hao, Zhang Huiru, Zhang Jinxuan, Wan Yinhua
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering Chinese Academy of Sciences Beijing P.R. China.
School of Chemical Engineering University of Chinese Academy of Sciences Beijing P.R. China.
Eng Life Sci. 2020 Jun 9;20(11):441-450. doi: 10.1002/elsc.202000018. eCollection 2020 Nov.
Biocatalytic membrane takes advantages of reaction-separation integration as well as enzyme immobilization, which has attracted increasing attentions in online detection and biomanufacturing. However, the high preparation cost, inferior comprehensive performance, and low stability limit its applications. Thus, besides enzyme immobilization, more efforts should be made in biocatalytic membrane configuration design for a specific application to enhance the synergistic effect of reaction and separation and improve its operating stability. This review summarized the recent progress on biocatalytic membrane preparation, discussed different membrane configurations for various applications, finally proposed several challenges and possible solutions, which provided directions and guides for the development and industrialization of biocatalytic membrane.
生物催化膜兼具反应-分离一体化以及酶固定化的优势，在在线检测和生物制造领域受到了越来越多的关注。然而，其高昂的制备成本、较差的综合性能以及较低的稳定性限制了它的应用。因此，除了酶固定化之外，还应在生物催化膜的构型设计方面投入更多努力，以针对特定应用增强反应与分离的协同效应并提高其操作稳定性。本综述总结了生物催化膜制备的最新进展，讨论了适用于各种应用的不同膜构型，最后提出了若干挑战及可能的解决方案，为生物催化膜的发展和工业化提供了方向与指导。
