Toledo-Pereyra L H, Simmons R L, Olson L C, Najarian J S
Ann Surg. 1977 Jan;185(1):128-31. doi: 10.1097/00000658-197701000-00021.
We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized, double-blind, prospective plan. There was no difference in the short-term or long-term function of either group of kidneys. Allopurinol does not appear to have as consistent a beneficial effect on non-ischemically damaged human kidneys as that observed experimentally on ischemically damaged canine organs.
我们研究了别嘌呤醇对移植后保存肾脏的临床效果。从脑死亡尸体获取的34对肾脏，在单独的盒中通过硅胶成分进行低温脉动灌注保存。按照随机、双盲、前瞻性方案，在一种灌注液中添加别嘌呤醇，另一种则不添加。两组肾脏的短期或长期功能均无差异。别嘌呤醇对未受缺血损伤的人类肾脏似乎不像在实验中对受缺血损伤的犬类器官那样具有始终如一的有益效果。
