• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan.台湾地区白豆蔻咀嚼行为与白细胞介素-16 基因型对口腔癌的交互作用。
In Vivo. 2020 Jul-Aug;34(4):1759-1764. doi: 10.21873/invivo.11969.
2
Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer.白细胞介素-16 遗传变异与台湾地区肺癌的显著关联。
In Vivo. 2020 May-Jun;34(3):1117-1123. doi: 10.21873/invivo.11883.
3
The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Infection to Gastric Cancer.白细胞介素-16 基因型、吸烟、饮酒和感染对胃癌的显著贡献。
In Vivo. 2024 Jan-Feb;38(1):90-97. doi: 10.21873/invivo.13414.
4
The Joint Effect of Interleukin-12B rs3212227 Genotype and Behavioral Factors on Oral Cancer Risk in Taiwanese.白细胞介素-12B rs3212227 基因型与行为因素对台湾人口腔癌风险的联合作用。
Anticancer Res. 2019 Dec;39(12):6515-6521. doi: 10.21873/anticanres.13866.
5
Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.胶原相关基因与槟榔诱导的口腔黏膜下纤维化易感性的相互作用
Cancer Epidemiol Biomarkers Prev. 2002 Jul;11(7):646-53.
6
The joint effect of hOGG1 single nucleotide polymorphism and betel quid chewing on oral cancer in Taiwan.HOGG1 单核苷酸多态性与嚼槟榔共同作用对台湾口腔癌的影响。
Anticancer Res. 2010 Oct;30(10):4205-8.
7
Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer.白细胞介素-16 基因的单核苷酸多态性 rs11556218、rs4778889、rs4072111 和 rs1131445 与卵巢癌的相关性。
Int J Mol Sci. 2024 Sep 24;25(19):10272. doi: 10.3390/ijms251910272.
8
Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer.DNA 修复基因 XPC 与口腔癌中吸烟和嚼槟榔行为的相互作用。
Cancer Genomics Proteomics. 2021 May-Jun;18(3 Suppl):441-449. doi: 10.21873/cgp.20270.
9
Accumulation of mitochondrial DNA deletions in human oral tissues -- effects of betel quid chewing and oral cancer.人类口腔组织中线粒体DNA缺失的积累——槟榔咀嚼与口腔癌的影响
Mutat Res. 2001 Jun 27;493(1-2):67-74. doi: 10.1016/s1383-5718(01)00160-7.
10
The Contribution of Interleukin-12A Genotypes to Oral Cancer Risk in Taiwanese.白细胞介素-12A 基因型对台湾人口腔癌风险的贡献。
Anticancer Res. 2020 Jul;40(7):3707-3712. doi: 10.21873/anticanres.14359.

引用本文的文献

1
Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk.白细胞介素-8和白细胞介素-16的基因变异及其与宫颈癌风险的关联。
Life (Basel). 2025 Jan 21;15(2):135. doi: 10.3390/life15020135.
2
Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer.白细胞介素-16 基因的单核苷酸多态性 rs11556218、rs4778889、rs4072111 和 rs1131445 与卵巢癌的相关性。
Int J Mol Sci. 2024 Sep 24;25(19):10272. doi: 10.3390/ijms251910272.
3
The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Infection to Gastric Cancer.白细胞介素-16 基因型、吸烟、饮酒和感染对胃癌的显著贡献。
In Vivo. 2024 Jan-Feb;38(1):90-97. doi: 10.21873/invivo.13414.
4
Association of Genotypes With Oral Cancer Risk.基因型与口腔癌风险的关联。
In Vivo. 2022 Nov-Dec;36(6):2669-2677. doi: 10.21873/invivo.13002.
5
The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk.PDCD6 多态性对口腔癌风险的贡献。
Cancer Genomics Proteomics. 2022 Jul-Aug;19(4):456-463. doi: 10.21873/cgp.20332.
6
Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan.环化酶 D1 启动子基因型与台湾地区哮喘易感性显著相关。
In Vivo. 2021 Jul-Aug;35(4):2041-2046. doi: 10.21873/invivo.12473.
7
Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer.DNA 修复基因 XPC 与口腔癌中吸烟和嚼槟榔行为的相互作用。
Cancer Genomics Proteomics. 2021 May-Jun;18(3 Suppl):441-449. doi: 10.21873/cgp.20270.
8
Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.MMP2 启动子基因型与台湾地区哮喘易感性的显著相关性。
In Vivo. 2020 Nov-Dec;34(6):3181-3186. doi: 10.21873/invivo.12153.
9
Association of functional polymorphisms with cancer and cardiovascular disease: a meta-analysis.功能多态性与癌症和心血管疾病的关联：一项荟萃分析。
Oncotarget. 2020 Sep 8;11(36):3405-3417. doi: 10.18632/oncotarget.27715.

本文引用的文献

1
Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan.miR146a 基因型与台湾儿童急性淋巴细胞白血病易感性的显著相关性
Cancer Genomics Proteomics. 2020 Mar-Apr;17(2):175-180. doi: 10.21873/cgp.20178.
2
The Association of Genotype With Pterygium.基因型与翼状胬肉的相关性。
In Vivo. 2020 Jan-Feb;34(1):51-56. doi: 10.21873/invivo.11744.
3
Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan.台湾 Caspase-8 基因型与口腔癌风险的关联。
In Vivo. 2019 Jul-Aug;33(4):1151-1156. doi: 10.21873/invivo.11585.
4
Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan.基质金属蛋白酶-2 启动子基因型对台湾地区鼻咽癌易感性和转移的影响。
Cancer Genomics Proteomics. 2019 Jul-Aug;16(4):287-292. doi: 10.21873/cgp.20133.
5
Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk.亚甲基四氢叶酸还原酶、维生素 D 受体和白细胞介素-16 基因多态性与肾细胞癌风险的关联。
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819859413. doi: 10.1177/1533033819859413.
6
Contribution of Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan.启动子基因型对台湾地区口腔癌易感性、复发及转移的影响
Anticancer Res. 2018 Dec;38(12):6821-6826. doi: 10.21873/anticanres.13055.
7
Peak of Standardized Uptake Value in Oral Cancer Predicts Survival Adjusting for Pathological Stage.口腔癌标准化摄取值峰值可预测经病理分期校正后的生存率。
In Vivo. 2018 Sep-Oct;32(5):1193-1198. doi: 10.21873/invivo.11363.
8
Association of Matrix Metalloproteinase-7 Genotypes to the Risk of Oral Cancer in Taiwan.台湾地区基质金属蛋白酶-7基因分型与口腔癌风险的关联
Anticancer Res. 2018 Apr;38(4):2087-2092. doi: 10.21873/anticanres.12448.
9
Interleukin-16 rs4778889 polymorphism contributes to the development of renal cell cancer in a Chinese population.白细胞介素-16 rs4778889基因多态性与中国人群肾细胞癌的发生有关。
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15228-33. eCollection 2015.
10
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.

台湾地区白豆蔻咀嚼行为与白细胞介素-16 基因型对口腔癌的交互作用。

Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan.

机构信息

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

出版信息

In Vivo. 2020 Jul-Aug;34(4):1759-1764. doi: 10.21873/invivo.11969.

DOI:10.21873/invivo.11969
PMID:32606144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7439915/
Abstract

BACKGROUND/AIM: Interleukin-16 (IL-16) is reported to play an important role in inflammation, carcinogenesis and tumoricidal processes, however, the contribution of IL-16 genotype to oral carcinogenesis is still largely unrevealed. Thus, the study aimed to investigate the contribution of IL-16 genotypes to Taiwan oral cancer risk.

MATERIALS AND METHODS

The genotypes of IL-16 rs4778889, rs11556218, and rs4072111 were revealed among 958 oral cancer cases and 958 control subjects by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).

RESULTS

First, the distributions of genotypic (p=0.0004) and allelic (p=0.0001) frequencies of IL-16 rs11556218 were significantly different between the case and control groups. In detail, the frequencies of IL-16 rs11556218 TG and GG were 28.1 and 5.8%, respectively, among oral cancer patients, significantly higher compared to those among controls (25.0% and 2.7%, respectively). Second, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Last, there was a synergistic effect of betel quid chewing behavior and risky IL-16 rs11556218 genotype on oral cancer risk.

CONCLUSION

The study indicates that the IL-16 rs11556218 G allele synergistically interacts with betel quid chewing behavior, contributing to increased risk of oral cancer in Taiwanese.

摘要

背景/目的：白细胞介素-16（IL-16）据报道在炎症、癌变和肿瘤杀伤过程中发挥重要作用，然而，IL-16 基因型对口腔癌变的贡献在很大程度上仍未被揭示。因此，本研究旨在探讨 IL-16 基因型对台湾人口腔癌风险的贡献。

材料与方法

通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP），在 958 例口腔癌病例和 958 例对照中揭示了 IL-16 rs4778889、rs11556218 和 rs4072111 的基因型。

结果

首先，IL-16 rs11556218 的基因型（p=0.0004）和等位基因（p=0.0001）频率分布在病例组和对照组之间存在显著差异。具体而言，口腔癌患者中 IL-16 rs11556218 TG 和 GG 的频率分别为 28.1%和 5.8%，明显高于对照组（分别为 25.0%和 2.7%）。其次，IL-16 rs4778889 或 IL-16 rs4072111 无差异。最后，嚼槟榔行为和风险 IL-16 rs11556218 基因型之间存在协同作用，增加了台湾人口腔癌的风险。

结论

本研究表明，IL-16 rs11556218 G 等位基因与嚼槟榔行为协同作用，增加了台湾人口腔癌的风险。