使用 7T 磁共振设备对前牙反合小鼠模型的颞下颌关节进行重复活体成像。
Repeated Live Imaging in the Temporomandibular Joint of an Anterior Crossbite Mouse Model Using a 7T Magnetic Resonance Device.
机构信息
Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo, Matsudo, Japan
Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.
出版信息
In Vivo. 2020 Jan-Feb;34(1):95-99. doi: 10.21873/invivo.11749.
BACKGROUND/AIM: Few studies have performed magnetic resonance (MR) imaging on live animals. The aim of this study was to perform 7T MR microimaging of the temporomandibular joint (TMJ) multiple times in the same living mice with malocclusion, and to compare between MR imaging and histopathological findings.
MATERIALS AND METHODS
Mice were examined by MR imaging at 3-4, 6 and 12 weeks following the attachment of a metal tube on the left mandibular incisor. Histopathological examination was done at 3, 6 and 12 weeks.
RESULTS
The detailed structure of the TMJ was evident from MR microimaging. The histopathological examination showed some changes in the cartilage, but no changes in the bone structure of these mice.
CONCLUSION
We successfully performed multiple 7T MR imaging in living mice. Even if the TMJ showed no obvious changes on MR images, minute changes may be present in the cartilage.
背景/目的：很少有研究对活体动物进行磁共振（MR）成像。本研究的目的是对患有错牙合畸形的同一只活小鼠进行多次颞下颌关节（TMJ）7T MR 微成像，并比较 MR 成像与组织病理学发现。
材料和方法
在将金属管附着于左侧下颌切牙后 3-4、6 和 12 周，对小鼠进行 MR 成像检查。在 3、6 和 12 周进行组织病理学检查。
结果
MR 微成像显示 TMJ 的详细结构。组织病理学检查显示软骨有一些变化，但这些小鼠的骨结构没有变化。
结论
我们成功地对活体小鼠进行了多次 7T MR 成像。即使 TMJ 在 MR 图像上没有明显变化，软骨也可能存在微小变化。
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