Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.
Biol Reprod. 2020 Apr 15;102(4):773-783. doi: 10.1093/biolre/ioz228.
Gonadotropin hormones and their receptors play a central role in the control of male and female reproduction. In recent years, there has been growing evidence surrounding the complexity of gonadotropin hormone/receptor signaling, with it increasingly apparent that the Gαs/cAMP/PKA pathway is not the sole signaling pathway that confers their biological actions. Here we review recent literature on the different receptor-receptor, receptor-scaffold, and receptor-signaling molecule complexes formed and how these modulate and direct gonadotropin hormone-dependent intracellular signal activation. We will touch upon the more controversial issue of extragonadal expression of FSHR and the differential signal pathways activated in these tissues, and lastly, highlight the open questions surrounding the role these gonadotropin hormone receptor complexes and how this will shape future research directions.
促性腺激素及其受体在男性和女性生殖的控制中起着核心作用。近年来，越来越多的证据表明，促性腺激素激素/受体信号具有复杂性，促性腺激素激素信号转导的 Gαs/cAMP/PKA 通路并不是赋予其生物学作用的唯一信号通路。在这里，我们回顾了关于不同受体-受体、受体支架和受体信号分子复合物形成的最新文献，以及这些复合物如何调节和指导促性腺激素激素依赖性细胞内信号激活。我们将讨论 FSHR 在性腺外表达以及这些组织中激活的不同信号通路这一更具争议性的问题，并最后强调围绕这些促性腺激素激素受体复合物的作用及其如何影响未来研究方向的开放性问题。
