Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Key Laboratory of Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, School of Chemistry and Chemical Engineering of Guangxi University for Nationalities, Nanning 530006, China.
Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Key Laboratory of Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, School of Chemistry and Chemical Engineering of Guangxi University for Nationalities, Nanning 530006, China.
Int J Biol Macromol. 2020 Feb 15;145:655-662. doi: 10.1016/j.ijbiomac.2019.12.220. Epub 2019 Dec 26.
A novel amphiphilic starch-based polymer carrier (R-St-PEG; R = hexadecyl, St = starch, PEG = polyethylene glycol) was prepared using tapioca starch. It was then applied as an effective carrier for encapsulated drug, and used for sustained drug release. First, tapioca starch was made to react with hexadecane bromide (R) for hydrophobic modification, and then the hydrophobically-modified tapioca starch molecules were grafted onto hydrophilic carboxyl-terminated PEG (mPEG-COOH). The drug-loading capacity and drug release behavior of R-St-PEG were systematically evaluated using curcumin as drug. The results show that the polymer has good drug-loading capacity and sustained-release properties, and it can act as an effective drug carrier. Thus, this study provides a suitable platform for preparing stable amphiphilic polymer carriers and broadens the application range of tapioca starch.
一种新型的两亲性淀粉基聚合物载体（R-St-PEG；R = 十六烷基，St = 淀粉，PEG = 聚乙二醇）是使用木薯淀粉制备的。然后，它被用作封装药物的有效载体，并用于持续药物释放。首先，使木薯淀粉与十六烷溴（R）反应进行疏水改性，然后将疏水改性的木薯淀粉分子接枝到亲水的羧基封端的 PEG（mPEG-COOH）上。用姜黄素作为药物，系统地评估了 R-St-PEG 的载药能力和药物释放行为。结果表明，该聚合物具有良好的载药能力和缓释性能，可作为有效的药物载体。因此，本研究为制备稳定的两亲性聚合物载体提供了合适的平台，并拓宽了木薯淀粉的应用范围。
