Department of Pharmacy, University of Malakand, Khyber Pakhtunkhwa (KP), 18000, Pakistan.
Department of Life Sciences, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, 31261, Saudi Arabia.
J Ethnopharmacol. 2020 Apr 6;251:112516. doi: 10.1016/j.jep.2019.112516. Epub 2019 Dec 26.
Various plant parts of Persicaria hydropiper (L.) Delarbre (Syn.: Polygonum hydropiper L., Family: Polygonaceae) are used in traditional medicine systems as astringent, sedative, antiseptic and also for the treatment of respiratory disorders, edema and snake bites. It is also used as a spice in many Asian countries.
The main aim of this review is to critically analyze the reported traditional uses, bioactive chemical constituents and pharmacological activities of P. hydropiper.
Scientific database including PubMed, Scopus, SciFinder and secondary resources including books and proceedings were searched using relevant terminologies related to P. hydropiper and available scientific information was critically analyzed.
Analysis of the scientific literature regarding the traditional uses revealed that P. hydropiper is used as a medicine and as spice in food preparations in various parts of the world. Various compounds including flavonoids, phenylpropanoid derivatives, and sesquiterpenoids among others were reported as active compounds. The extracts and compounds from P. hydropiper showed diverse biological activities including anti-inflammatory, antioxidant, cytotoxic, antimicrobial activities, etc. CONCLUSION: Although various research reports showed diverse biological activities for extracts and compounds obtained from P. hydropiper, very few studies were performed using animal models. Many of these studies also lacked proper experimental setting such as use of positive and negative controls and selection of dose as in most of these studies very high doses of extracts were administered. Further, as P. hydropiper is widely used in the treatment of snake bites and insect bites, such effects of extracts and/or compounds are not well explored. Future studies on P. hydropiper should be focused to establish the links between the traditional uses, active compounds and reported pharmacological activities.
贯叶蓼（Polygonum hydropiper L.，蓼科）的不同植物部位在传统医学体系中被用作收敛剂、镇静剂、防腐剂，也用于治疗呼吸紊乱、水肿和蛇咬伤。它在许多亚洲国家也被用作香料。
本次综述的主要目的是批判性地分析贯叶蓼的传统用途、生物活性化学成分和药理学活性。
使用与贯叶蓼相关的术语和现有科学信息，对包括 PubMed、Scopus、SciFinder 在内的科学数据库以及书籍和会议记录等二级资源进行了搜索，并对可用的科学信息进行了批判性分析。
对有关贯叶蓼传统用途的科学文献进行分析后发现，贯叶蓼在世界各地被用作药物和食品制剂中的香料。已报道的活性化合物包括类黄酮、苯丙素衍生物和倍半萜等多种化合物。贯叶蓼的提取物和化合物表现出多种生物活性，包括抗炎、抗氧化、细胞毒性、抗菌活性等。
尽管各种研究报告显示贯叶蓼的提取物和化合物具有多种生物活性，但使用动物模型进行的研究很少。这些研究中的许多研究还缺乏适当的实验设置，例如使用阳性和阴性对照以及选择剂量，因为在这些研究中的大多数研究中，都使用了非常高剂量的提取物。此外，由于贯叶蓼广泛用于治疗蛇咬伤和昆虫咬伤，因此对提取物和/或化合物的这些作用尚未得到充分探索。未来对贯叶蓼的研究应侧重于建立传统用途、活性化合物和报道的药理学活性之间的联系。
