Smurfit Institute of Genetics, Trinity College Dublin, Lincoln Place Gate, Dublin, Ireland.
Adv Exp Med Biol. 2019;1185:329-333. doi: 10.1007/978-3-030-27378-1_54.
The neural retina is protected from the blood circulation by the presence of a highly selective inner blood-retinal barrier (iBRB). The presence of sophisticated tight junctions (TJs) between the endothelial cells (ECs) of the iBRB helps mediate the very low passive permeability of the tissue, permitting entry of nutrients into the retina but excluding harmful toxic material and inflammatory cells. The most highly enriched TJ protein is claudin-5, which is critical in mediating the passive paracellular diffusion barrier properties of the iBRB. In numerous retinal degeneration pathologies, TJ disruption is observed, and a more refined understanding of this disruption could be used for therapeutic benefit.
神经视网膜受到高度选择性的内血视网膜屏障 (iBRB) 的保护。iBRB 内皮细胞 (ECs) 之间存在复杂的紧密连接 (TJ)，有助于调节组织的极低被动通透性，允许营养物质进入视网膜，但排除有害的有毒物质和炎症细胞。最丰富的 TJ 蛋白是 Claudin-5，它对于调节 iBRB 的被动细胞旁扩散屏障特性至关重要。在许多视网膜变性疾病中，观察到 TJ 破坏，更精细地了解这种破坏可能用于治疗获益。
