Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, MD, USA.
Adv Exp Med Biol. 2019;1185:445-449. doi: 10.1007/978-3-030-27378-1_73.
Pigment epithelium-derived factor (PEDF) is involved in signal transduction cascades necessary for protection of the retina. The interaction between PEDF and retinal cells elicits neuroprotective effects in vitro and in vivo. The direct substrates and signaling mechanisms involved in the survival response derived from such interaction are beginning to be revealed. It is of interest to elucidate cell death pathways that are crucial for the retinoprotective response of PEDF for the identification of targets that interfere with retina degeneration with potential therapeutic value. Here we review the molecular pathways triggered by PEDF that are involved in retinal survival activity.
色素上皮衍生因子 (PEDF) 参与视网膜保护所需的信号转导级联反应。PEDF 与视网膜细胞的相互作用在体外和体内引发神经保护作用。这种相互作用产生的生存反应所涉及的直接底物和信号机制开始被揭示。阐明对 PEDF 的视网膜保护反应至关重要的细胞死亡途径对于鉴定具有潜在治疗价值的干扰视网膜变性的靶点具有重要意义。在这里，我们综述了 PEDF 触发的涉及视网膜存活活性的分子途径。
