Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Laboratorio 5 Pubertad, Unidad de Investigación en Biología de la Reproducción, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Int J Toxicol. 2020 Jan/Feb;39(1):20-29. doi: 10.1177/1091581819894529. Epub 2019 Dec 30.
Vanadium is a metal present in particulate matter and its reprotoxic effects have been demonstrated in males and pregnant females in animal models. However, the effects of this metal on the reproductive organs of nonpregnant females have not been sufficiently studied. In a vanadium inhalation model in nonpregnant female mice, we found anestrous and estrous cycle irregularity, as well as low serum concentrations of 17β-estradiol and progesterone. A decrease in the diameter of secondary and preovulatory follicles, as well as a thickening of the myometrium and endometrial stroma, was observed in the vanadium-treated mice. There was no difference against the control group with respect to the presence of the estrogen receptor α in the uterus of the animals during the estrous stage. Our results indicate that when vanadium is administered by inhalation, effects are observed on the female reproductive organs and the production of female sex hormones.
钒是一种存在于颗粒物中的金属，其生殖毒性已在动物模型中得到证实，包括雄性和怀孕雌性动物。然而，这种金属对未怀孕雌性动物的生殖器官的影响尚未得到充分研究。在一项非怀孕雌性小鼠的钒吸入模型中，我们发现了乏情和发情周期不规律，以及血清 17β-雌二醇和孕酮浓度降低。在接受钒处理的小鼠中，观察到次级卵泡和排卵前卵泡的直径减小，以及子宫平滑肌和子宫内膜基质增厚。在发情期，动物子宫中雌激素受体 α 的存在与对照组没有差异。我们的结果表明，当通过吸入给予钒时，会对雌性生殖器官和雌性性激素的产生产生影响。
