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[大鼠对侧半球损伤后运动皮层局部组织的重构]

[Restructuring of the topical organization of the rat motor cortex after damage to the opposite hemisphere].

作者信息

Ptitsyna I B, Vol'nova A B, Lenkov D N

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 May-Jun;38(3):506-12.

PMID:3188646
Abstract

Topical organization of the motor cortex was compared in outbred rats by the method of intracortical microstimulation in the norm and in different periods after unilateral partial decortication of the motor projection (MP) of the hind-leg. Stable state of the MPs of the fore- and hind-limbs was in the norm, and within their bounds there was an individual variability of MP zones of separate joints. After the operation, the reconstruction of the motor cortex organization in the opposite hemisphered appeared in later periods, in 5-7 months. Expansion was observed of the boundaries of the excitable area in caudal direction and reduction of the part of responses of the limbs distal muscles as compared to proximal ones and of the body muscles. 8-16 months after the operation, the reactions of axial muscles, including the ipsi- and bilateral ones, became more expressed.

摘要

通过皮质内微刺激方法,在正常情况下以及单侧部分切除后肢运动投射(MP)后的不同时期,对远交系大鼠运动皮质的局部组织进行了比较。正常情况下前肢和后肢MP处于稳定状态,在其范围内,各个关节的MP区域存在个体差异。手术后,对侧半球运动皮质组织的重建在后期出现,即5 - 7个月时。与近端肌肉和身体肌肉相比,观察到可兴奋区域的边界向尾侧扩展,肢体远端肌肉的反应部分减少。手术后8 - 16个月,包括同侧和双侧的轴向肌肉反应变得更加明显。

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