Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
Fitoterapia. 2020 Mar;141:104468. doi: 10.1016/j.fitote.2019.104468. Epub 2019 Dec 28.
Thirteen new withanolide aglycones, baimantuoluolines L-X (1-13) and one new withanolide glycoside, baimantuoluoside J (14) were isolated from Datura metel L. flowers. The structures of the new compounds were elucidated by the detailed analysis of 1D and 2D NMR techniques and mass spectrometry, together with the closely related literatures. Meanwhile, all isolated compounds were evaluated for their immunosuppressive activities against mice splenocyte proliferation and antiproliferative activities against human gastric adenocarcinoma cells (SGC-7901), human hepatoma (HepG2), and human breast cancer (MCF-7) in vitro. It was found that compounds 1-14 showed obvious immunosupressive effects and some of them have moderated antiproliferative activities.
从曼陀罗花中分离得到 13 个新的薯蓣皂苷元糖苷，分别命名为 baimantuoluolines L-X（1-13）和一个新的薯蓣皂苷元糖苷 baimantuoluoside J（14）。通过 1D 和 2D NMR 技术以及质谱分析，并结合相关文献，详细解析了这些新化合物的结构。同时，对所有分离得到的化合物进行了免疫抑制活性实验（检测对小鼠脾细胞增殖的抑制作用）和体外抗增殖活性实验（检测对人胃癌细胞（SGC-7901）、人肝癌细胞（HepG2）和人乳腺癌细胞（MCF-7）的抑制作用）。结果表明，化合物 1-14 具有明显的免疫抑制作用，其中一些化合物具有适度的抗增殖活性。
