Wang Xiao-Yan, He Jun, Bai Hong-Jin, Gao Pin-Yi, Gan He, Yang Ting, Zhang Wei-Ku, Xu Jie-Kun
School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China.
Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, P. R. China.
Chem Biodivers. 2019 Apr;16(4):e1900004. doi: 10.1002/cbdv.201900004. Epub 2019 Mar 15.
Three new withanolides (1-3), named as daturanolide A-C, along with six known withanolides (4-9) were isolated from the flowers of Datura metel L. Their structures with absolute configurations were elucidated by a series of spectroscopic methods, electronic circular dichroism (ECD) analyses, and X-ray crystallography. All the isolates were evaluated for cytotoxicity against five human cancer cell lines (HCT116, U87-MG, NCI-H460, BGC823, and HepG2), and 6 exhibited marked cytotoxicity.
从白花曼陀罗的花朵中分离出三种新的睡茄内酯（1-3），命名为曼陀罗内酯A-C，以及六种已知的睡茄内酯（4-9）。通过一系列光谱方法、电子圆二色（ECD）分析和X射线晶体学确定了它们的结构及其绝对构型。评估了所有分离物对五种人类癌细胞系（HCT116、U87-MG、NCI-H460、BGC823和HepG2）的细胞毒性，其中6种表现出显著的细胞毒性。
