曼陀罗内酯A - C，从白花曼陀罗中分离得到的三种新的维甾烷醇内酯及其细胞毒性活性
Daturanolide A-C, Three New Withanolides from Datura metel L. and Their Cytotoxic Activities.
作者信息
Wang Xiao-Yan, He Jun, Bai Hong-Jin, Gao Pin-Yi, Gan He, Yang Ting, Zhang Wei-Ku, Xu Jie-Kun
机构信息
School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China.
Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, P. R. China.
出版信息
Chem Biodivers. 2019 Apr;16(4):e1900004. doi: 10.1002/cbdv.201900004. Epub 2019 Mar 15.
Three new withanolides (1-3), named as daturanolide A-C, along with six known withanolides (4-9) were isolated from the flowers of Datura metel L. Their structures with absolute configurations were elucidated by a series of spectroscopic methods, electronic circular dichroism (ECD) analyses, and X-ray crystallography. All the isolates were evaluated for cytotoxicity against five human cancer cell lines (HCT116, U87-MG, NCI-H460, BGC823, and HepG2), and 6 exhibited marked cytotoxicity.
从白花曼陀罗的花朵中分离出三种新的睡茄内酯（1-3），命名为曼陀罗内酯A-C，以及六种已知的睡茄内酯（4-9）。通过一系列光谱方法、电子圆二色（ECD）分析和X射线晶体学确定了它们的结构及其绝对构型。评估了所有分离物对五种人类癌细胞系（HCT116、U87-MG、NCI-H460、BGC823和HepG2）的细胞毒性，其中6种表现出显著的细胞毒性。
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