Ma Junpeng, Zhang Yuan, Chen Liangpeng, Chen Yujia, Yang Yang, Li Da, Wang Liang, Zhang Junting, Wu Zhen
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Brain Tumor, Beijing, China.
World Neurosurg. 2020 Apr;136:e196-e203. doi: 10.1016/j.wneu.2019.12.108. Epub 2019 Dec 27.
To investigate the expression characteristics, correlations with clinical factors, and prognostic values of phosphatase and tensin homolog (PTEN) and Ki-67 in cranial meningiomas.
The expression of PTEN and Ki-67 at the mRNA level was analyzed in 34 frozen meningiomas. Clinical data collection, follow-up, correlations, and survival analyses were performed.
Twenty-two men and 12 women were included in the study, with a median age of 52.72 ± 11.72 years on admission. The average expression levels of PTEN and Ki-67 were 2.71 ± 1.73 and 0.50 ± 0.57, respectively. The World Health Organization grade III meningiomas exhibited significantly lower levels of PTEN (P = 0.037), whereas grade I meningiomas expressed significantly lower levels of Ki-67 (P = 0.001). For recurrent lesions, the mean Ki-67 expression level was 0.97 ± 0.76, which was significantly greater than that of primary meningiomas with a mean value of 0.25 ± 0.13 (P < 0.001). The Ki-67 expression level was positively correlated with the tumor volume (P < 0.01) and negatively correlated with preoperative Karnofsky Performance Status scale (KPS, P < 0.01), postoperative KPS (P < 0.05), and follow-up KPS (P < 0.01). However, the PTEN expression level did not correlate with these variables. Based on the multivariate Cox analysis, Ki-67 expression level (P < 0.001, hazard ratio [HR] 8.16, 95% confidence interval [CI] 2.86-23.29), and PTEN expression level (P = 0.018, HR 0.47, 95% CI 0.25-0.88) were independent prognostic factors for tumor recurrence. Ki-67 (P = 0.001, HR 19.73, 95% CI 3.65-106.61) and PTEN expression levels (P = 0.024, HR 0.36, 95% CI 0.15-0.88) were also independent prognostic factors for mortality.
A low PTEN expression and a high Ki-67 expression could predict malignancy in cranial meningiomas.
探讨磷酸酶和张力蛋白同源物（PTEN）及Ki-67在颅内脑膜瘤中的表达特征、与临床因素的相关性及预后价值。
分析34例冰冻脑膜瘤中PTEN和Ki-67在mRNA水平的表达。进行临床资料收集、随访、相关性分析及生存分析。
本研究纳入22例男性和12例女性，入院时中位年龄为52.72±11.72岁。PTEN和Ki-67的平均表达水平分别为2.71±1.73和0.50±0.57。世界卫生组织III级脑膜瘤的PTEN水平显著较低（P = 0.037），而I级脑膜瘤的Ki-67表达水平显著较低（P = 0.001）。对于复发病变，Ki-67的平均表达水平为0.97±0.76，显著高于原发性脑膜瘤的平均值0.25±0.13（P < 0.001）。Ki-67表达水平与肿瘤体积呈正相关（P < 0.01），与术前卡氏功能状态量表（KPS）、术后KPS（P < 0.05）及随访KPS（P < 0.01）呈负相关。然而，PTEN表达水平与这些变量无关。基于多因素Cox分析，Ki-67表达水平（P < 0.001，风险比[HR] 8.16，95%置信区间[CI] 2.86 - 23.29）和PTEN表达水平（P = 0.018，HR 0.47，95% CI 0.25 - 0.88）是肿瘤复发的独立预后因素。Ki-67（P = 0.001，HR 19.73，95% CI 3.65 - 106.61）和PTEN表达水平（P = 0.024，HR 0.36，95% CI 0.15 - 0.88）也是死亡的独立预后因素。
PTEN低表达和Ki-67高表达可预测颅内脑膜瘤的恶性程度。
