Li M Y, Bai Y Q, Liu Y
Department of Rheumatology and Immunology, Subsidiary Hospital, Southwestern Medical University, Luzhou, Sichuan Province 646000, China.
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Nei Ke Za Zhi. 2020 Jan 1;59(1):58-61. doi: 10.3760/cma.j.issn.0578-1426.2020.01.010.
The purpose of this study is to investigate the matrix metalloproteinase-3 (MMP-3) levels in patients with systemic lupus erythematosus (SLE) and its significance in identifying disease activity and pulmonary infections. A total of 122 SLE patients were enrolled, including 21 with pulmonary infections, 16 with arthritis, 26 with nephritis, 10 with vasculitis, and 23 healthy controls. Serum MMP-3, C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (HPT) levels were measured in all subjects. The results showed that the levels of MMP-3 in SLE combined with pulmonary infections [(230.10±44.92) μg/L], arthritis [(140.20±20.76) μg/L], nephritis [(155.40±23.36) μg/L] were higher than those in SLE only [(91.74±10.47) μg/L]. The levels of MMP-3 [(210.30±45.71) μg/L], CRP [(12.11±5.21) mg/L], HPT [(1.57±0.23) g/L] in active SLE combined with pulmonary infections were higher than those inactive SLE without pulmonary infections including MMP-3 [(124.00±15.22) μg/L], CRP [(7.76±2.96) mg/L], HPT [(0.89±0.09) g/L]. The levels of CRP [(10.03±2.70) mg/L], SAA [(89.22±36.77) mg/L] in active SLE with pulmonary infections and CRP[(7.76±2.96) mg/L], SAA [(60.22±19.7) mg/L] in active SLE without pulmonary infections were higher than CRP [(1.90±0.39) mg/L], SAA [(17.60±3.89) mg/L] in stable SLE with pulmonary infections. It suggests that the levels of CRP and SAA are elevated in active SLE with pulmonary infections. Serum MMP-3 in combination with CRP may assist in differentiating from SLE pulmonary infections.
本研究的目的是调查系统性红斑狼疮（SLE）患者的基质金属蛋白酶-3（MMP-3）水平及其在识别疾病活动度和肺部感染中的意义。共纳入122例SLE患者，其中21例合并肺部感染，16例有关节炎，26例有肾炎，10例有血管炎，以及23名健康对照者。检测了所有受试者的血清MMP-3、C反应蛋白（CRP）、血清淀粉样蛋白A（SAA）和触珠蛋白（HPT）水平。结果显示，SLE合并肺部感染组[（230.10±44.92）μg/L]、关节炎组[（140.20±20.76）μg/L]、肾炎组[（155.40±23.36）μg/L]的MMP-3水平高于单纯SLE组[（91.74±10.47）μg/L]。活动期SLE合并肺部感染组的MMP-3[（210.30±45.71）μg/L]、CRP[（12.11±5.21）mg/L]、HPT[（1.57±0.23）g/L]水平高于非活动期SLE无肺部感染组，后者的MMP-3[（124.00±15.22）μg/L]、CRP[（7.76±2.96）mg/L]、HPT[（0.89±0.09）g/L]。活动期SLE合并肺部感染组的CRP[（10.03±2.70）mg/L]、SAA[（89.22±36.77）mg/L]水平以及活动期SLE无肺部感染组的CRP[（7.76±2.96）mg/L]、SAA[（60.22±19.7）mg/L]水平高于稳定期SLE合并肺部感染组的CRP[（1.90±0.39）mg/L]、SAA[（17.
